PMID- 27232584
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20220129
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 71
IP  - 11
DP  - 2016 Nov
TI  - The Patient-Oriented Eczema Measure in young children: responsiveness and minimal 
      clinically important difference.
PG  - 1620-1625
LID - 10.1111/all.12942 [doi]
AB  - BACKGROUND: The Patient-Oriented Eczema Measure (POEM) has been recommended as 
      the core patient-reported outcome measure for trials of eczema treatments. Using 
      data from the Choice of Moisturiser for Eczema Treatment randomized feasibility 
      study, we assess the responsiveness to change and determine the minimal 
      clinically important difference (MCID) of the POEM in young children with eczema. 
      METHODS: Responsiveness to change by repeated administrations of the POEM was 
      investigated in relation to change recalled using the Parent Global Assessment 
      (PGA) measure. Five methods of determining the MCID of the POEM were employed; 
      three anchor-based methods using PGA as the anchor: the within-patient score 
      change, between-patient score change and sensitivity and specificity method, and 
      two distribution-based methods: effect size estimate and the one half standard 
      deviation of the baseline distribution of POEM scores. RESULTS: Successive POEM 
      scores were found to be responsive to change in eczema severity. The MCID of the 
      POEM change score, in relation to a slight improvement in eczema severity as 
      recalled by parents on the PGA, estimated by the within-patient score change 
      (4.27), the between-patient score change (2.89) and the sensitivity and 
      specificity method (3.00) was similar to the one half standard deviation of the 
      POEM baseline scores (2.94) and the effect size estimate (2.50). CONCLUSIONS: The 
      Patient-Oriented Eczema Measure as applied to young children is responsive to 
      change, and the MCID is around 3. This study will encourage the use of POEM and 
      aid in determining sample size for future randomized controlled trials of 
      treatments for eczema in young children.
CI  - (c) 2016 The Authors. Allergy Published by John Wiley & Sons Ltd.
FAU - Gaunt, D M
AU  - Gaunt DM
AD  - Bristol Randomised Trials Collaboration, School of Social and Community Medicine, 
      University of Bristol, Bristol, UK. daisy.gaunt@bristol.ac.uk.
FAU - Metcalfe, C
AU  - Metcalfe C
AD  - Bristol Randomised Trials Collaboration, School of Social and Community Medicine, 
      University of Bristol, Bristol, UK.
FAU - Ridd, M
AU  - Ridd M
AD  - Centre for Academic Primary Care, School of Social and Community Medicine, 
      University of Bristol, Bristol, UK.
LA  - eng
GR  - PB-PG-0712-28056/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160713
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Eczema/diagnosis/*epidemiology/therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Minimal Clinically Important Difference
MH  - Patient Reported Outcome Measures
MH  - ROC Curve
MH  - Randomized Controlled Trials as Topic
MH  - Time Factors
PMC - PMC5113674
OTO - NOTNLM
OT  - Patient-Oriented Eczema Measure
OT  - atopic eczema
OT  - minimal clinically important difference
OT  - paediatrics
OT  - responsiveness
EDAT- 2016/05/28 06:00
MHDA- 2017/11/29 06:00
PMCR- 2016/11/17
CRDT- 2016/05/28 06:00
PHST- 2016/05/26 00:00 [accepted]
PHST- 2016/05/28 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2016/05/28 06:00 [entrez]
PHST- 2016/11/17 00:00 [pmc-release]
AID - ALL12942 [pii]
AID - 10.1111/all.12942 [doi]
PST - ppublish
SO  - Allergy. 2016 Nov;71(11):1620-1625. doi: 10.1111/all.12942. Epub 2016 Jul 13.