PMID- 27233528
OWN - NLM
STAT- MEDLINE
DCOM- 20180115
LR  - 20180402
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 64
IP  - 6
DP  - 2016 Aug
TI  - Association of serum pentraxin 3 concentrations with diabetic nephropathy.
PG  - 1124-7
LID - 10.1136/jim-2016-000082 [doi]
AB  - Pentraxin 3 (PTX3), a member of a superfamily of conserved proteins, attenuates 
      renal damage in diabetic mice. This study aims to determine whether serum PTX3 
      concentrations are correlated with the presence of diabetic nephropathy (DN). A 
      total of 160 patients with type 2 diabetes mellitus (T2DM) and 54 healthy 
      subjects were enrolled in this study. Patients with T2DM were divided into three 
      groups in accordance with the levels of urinary albumin excretion (UAE). Serum 
      PTX3 concentrations were determined using an ELISA kit. Serum PTX3 concentrations 
      were significantly higher in patients with T2DM compared with the controls. 
      Patients with T2DM with macroalbuminuria showed higher serum PTX3 concentrations 
      compared with the other three groups. However, there were no significant 
      differences of serum PTX3 concentrations between patients with T2DM with 
      normoalbuminuria and microalbuminuria. Furthermore, a simple regression analysis 
      has shown that serum PTX3 concentrations in patients with T2DM were negatively 
      correlated with body mass index, and positively correlated with blood urea 
      nitrogen, serum creatinine, and UAE. Serum PTX3 concentrations are correlated 
      with DN.
CI  - Copyright (c) 2016 American Federation for Medical Research.
FAU - Wang, Rui
AU  - Wang R
AD  - Department of Blood Transfusion, Qilu Hospital of Shandong University (Qingdao), 
      Shandong, People's Republic of China.
FAU - Zhang, Jietao
AU  - Zhang J
AD  - Department of General Medicine, Affiliated Hospital of Qingdao University, 
      Qingdao, Shandong, People's Republic of China.
FAU - Hu, Wenchao
AU  - Hu W
AD  - Department of Endocrinology, Qilu Hospital of Shandong University (Qingdao), 
      Shandong, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20160527
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (Serum Amyloid P-Component)
RN  - 148591-49-5 (PTX3 protein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein/*metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood
MH  - Diabetic Nephropathies/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Serum Amyloid P-Component/*metabolism
OTO - NOTNLM
OT  - Diabetic Nephropathies
OT  - Inflammation
EDAT- 2016/05/29 06:00
MHDA- 2018/01/16 06:00
CRDT- 2016/05/29 06:00
PHST- 2016/05/07 00:00 [accepted]
PHST- 2016/05/29 06:00 [entrez]
PHST- 2016/05/29 06:00 [pubmed]
PHST- 2018/01/16 06:00 [medline]
AID - jim-2016-000082 [pii]
AID - 10.1136/jim-2016-000082 [doi]
PST - ppublish
SO  - J Investig Med. 2016 Aug;64(6):1124-7. doi: 10.1136/jim-2016-000082. Epub 2016 
      May 27.