PMID- 27234778
OWN - NLM
STAT- MEDLINE
DCOM- 20161223
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 48
IP  - 3
DP  - 2016 Apr
TI  - Oxygen Uptake Efficiency Slope Predicts Major Cardiac Events in Patients With 
      End-Stage Heart Failure.
PG  - 956-8
LID - S0041-1345(16)00125-1 [pii]
LID - 10.1016/j.transproceed.2015.10.076 [doi]
AB  - INTRODUCTION: Oxygen uptake efficiency slope (OUES) has been shown as a predictor 
      of stable heart failure (HF) survival. However, there is a lack of evidence for 
      end-stage HF. OBJECTIVES: We aimed to investigate the prognostic value of OUES in 
      end-stage HF patients. METHODS: The study design was a retrospective cohort. 
      End-staged HF patients who had cardiopulmonary exercise testing (CPET) for 
      evaluation between 2004 and 2009 were included. The primary outcomes were cardiac 
      death and heart transplantation. The independent survival predictors were 
      determined using Cox regression hazard model adjusted for demographics, New York 
      Heart Association (NYHA) classification, medication, and left ventricular 
      ejection fraction (LVEF). The Kaplan-Meier survival curves and log-rank test were 
      used. Probability values less than .05 were considered significant. RESULTS: Mean 
      age of the 128 patients was 50 +/- 12 years and 93 were male. Mean LVEF was 23% +/- 
      9%. Forty-three subjects suffered cardiac events (5 cardiac deaths and 38 urgent 
      heart transplantations) during the 2-year follow-up period. Cox regression 
      indicated that OUES and diuretics were significant predictors of 2-year survival, 
      although peak oxygen uptake and ventilatory equivalent of carbon dioxide were 
      not. Patients with high OUES (>/=1.6) had a higher survival rate (P < .001; odds 
      ratio [OR], 13.10; 95% confidence interval [CI], 3.30-58.63). The Kaplan-Meier 
      curves show survival was significantly higher in those with OUES >/=1.6. 
      CONCLUSIONS: OUES might be an aid in prognosis of patients with end-stage HF and 
      useful in the assessment of patients unable to perform maximal exercise testing.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Lin, Y-S
AU  - Lin YS
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
FAU - Huang, H-Y
AU  - Huang HY
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan. Electronic address: 
      856038@gmail.com.
FAU - Lin, W-H
AU  - Lin WH
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
FAU - Wei, J
AU  - Wei J
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
FAU - Chen, J-C
AU  - Chen JC
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
FAU - Kuo, L-Y
AU  - Kuo LY
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
FAU - Hsu, C-L
AU  - Hsu CL
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
FAU - Chen, B-Y
AU  - Chen BY
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
FAU - Cheng, F-H
AU  - Cheng FH
AD  - Heart Center, Cheng Hsin General Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Exercise Test
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*metabolism/mortality/physiopathology
MH  - *Heart Transplantation
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Oxygen/*metabolism
MH  - Oxygen Consumption/*physiology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate/trends
MH  - Taiwan/epidemiology
MH  - Ventricular Function, Left/physiology
EDAT- 2016/05/29 06:00
MHDA- 2016/12/24 06:00
CRDT- 2016/05/29 06:00
PHST- 2015/09/17 00:00 [received]
PHST- 2015/10/03 00:00 [accepted]
PHST- 2016/05/29 06:00 [entrez]
PHST- 2016/05/29 06:00 [pubmed]
PHST- 2016/12/24 06:00 [medline]
AID - S0041-1345(16)00125-1 [pii]
AID - 10.1016/j.transproceed.2015.10.076 [doi]
PST - ppublish
SO  - Transplant Proc. 2016 Apr;48(3):956-8. doi: 10.1016/j.transproceed.2015.10.076.