PMID- 27237758
OWN - NLM
STAT- MEDLINE
DCOM- 20170203
LR  - 20220408
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 7
DP  - 2016 May
TI  - Distribution-based estimates of minimum clinically important difference in 
      cognition, arm function and lower body function after slow release-fampridine 
      treatment of patients with multiple sclerosis.
PG  - 58-60
LID - S2211-0348(16)30028-1 [pii]
LID - 10.1016/j.msard.2016.03.007 [doi]
AB  - OBJECTIVE: To provide distribution-based estimates of the minimal clinical 
      important difference (MCID) after slow release fampridine treatment on cognition 
      and functional capacity in people with MS (PwMS). METHOD: MCID values were 
      determined after SR-Fampridine treatment in 105 PwMS. Testing included the Timed 
      25 Foot Walk (T25FW), the Symbol Digit Modalities Test (SDMT), the Six Spot Step 
      Test (SSST), the 9-Hole-Peg-Test (9-HPT), and the 5-Time-Sit-To-Stand test 
      (5-STS). RESULTS: MCID values: T25FW 17.8% (9.1-17.8), SDMT 17.1% (9.2-17.1), 
      SSST 16.7% (8.5-16.7), 9-HPT 15.3% (0-15.3), and 5-STS 34.6% (16.9-34.6). 
      CONCLUSION: This study presents distribution-based estimates of MCID values for 
      the SSST, the 9-HPT, and the 5-STS and confirms MCID estimates for the T25FW and 
      the SDMT.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Jensen, H B
AU  - Jensen HB
AD  - Institute of Regional Health Research, University of Southern Denmark, Denmark; 
      MS-Clinic of Southern Jutland (Sonderborg, Vejle, Esbjerg), Department of 
      Neurology, Sonderborg Hospital, Denmark. Electronic address: 
      henrik.boye.jensen@rsyd.dk.
FAU - Mamoei, Sepehr
AU  - Mamoei S
AD  - MS-Clinic of Southern Jutland (Sonderborg, Vejle, Esbjerg), Department of 
      Neurology, Sonderborg Hospital, Denmark.
FAU - Ravnborg, M
AU  - Ravnborg M
AD  - Department of Neurology, Odense University Hospital, Denmark.
FAU - Dalgas, U
AU  - Dalgas U
AD  - Department of Public Health, Section of Sport Science, Aarhus University, 
      Denmark.
FAU - Stenager, E
AU  - Stenager E
AD  - Institute of Regional Health Research, University of Southern Denmark, Denmark; 
      MS-Clinic of Southern Jutland (Sonderborg, Vejle, Esbjerg), Department of 
      Neurology, Sonderborg Hospital, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20160318
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
RN  - 0 (Potassium Channel Blockers)
RN  - BH3B64OKL9 (4-Aminopyridine)
SB  - IM
MH  - 4-Aminopyridine/*therapeutic use
MH  - Arm/physiopathology
MH  - Cognition/*drug effects
MH  - *Disability Evaluation
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Activity/*drug effects/physiology
MH  - Multiple Sclerosis/*drug therapy/physiopathology/psychology
MH  - Potassium Channel Blockers/*therapeutic use
MH  - Reference Values
MH  - Walking/physiology
OTO - NOTNLM
OT  - Axonal loss
OT  - Change
OT  - Demyelination
OT  - MCID
OT  - Minimal clinically important difference
OT  - Multiple sclerosis
OT  - Rehabilitation
EDAT- 2016/05/31 06:00
MHDA- 2017/02/06 06:00
CRDT- 2016/05/31 06:00
PHST- 2015/04/08 00:00 [received]
PHST- 2015/09/13 00:00 [revised]
PHST- 2016/03/17 00:00 [accepted]
PHST- 2016/05/31 06:00 [entrez]
PHST- 2016/05/31 06:00 [pubmed]
PHST- 2017/02/06 06:00 [medline]
AID - S2211-0348(16)30028-1 [pii]
AID - 10.1016/j.msard.2016.03.007 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2016 May;7:58-60. doi: 10.1016/j.msard.2016.03.007. Epub 
      2016 Mar 18.