PMID- 2723998
OWN - NLM
STAT- MEDLINE
DCOM- 19890705
LR  - 20190710
IS  - 0022-3468 (Print)
IS  - 0022-3468 (Linking)
VI  - 24
IP  - 1
DP  - 1989 Jan
TI  - Decreased immunogenicity of fetal kidneys: the role of passenger leukocytes.
PG  - 59-63; discussion 63
AB  - Early in gestation, fetal rat kidneys are less immunogenic than in later fetal 
      stages, and also less immunogenic than early-gestation fetal hepatic tissue. The 
      purpose of this study was to test this observation in an allogeneic model, and to 
      explore the basis of the decreased immunogenicity of early-gestation fetal 
      kidneys. Kidneys were harvested from Fischer (FSH) fetal rats on the 15th, 17th, 
      18th, and 19th gestational day (GD), and then grafted under the kidney capsule of 
      incompatible Wistar/Furth (W/F) adult male rats. Fetal hepatic tissue was 
      harvested from 15th-GD FSH fetal rats, and then grafted under the kidney capsule 
      of W/F adult male rats. Each recipient received either one kidney or a 3-mm piece 
      of liver. Graft biopsies were obtained 10, 20, 30, and 40 days 
      posttransplantation, and evaluated histologically. The severity of rejection was 
      divided into three grades according to the degree of mononuclear infiltration and 
      percentage of original fetal structures preserved. All fetal hepatic grafts were 
      completely rejected (grade III) by the tenth posttransplantation day. In 
      contrast, the degree of rejection of the kidneys was age-dependent. Fifteenth-GD 
      kidneys showed a minimal or moderate degree of rejection (grade I or II) at 10, 
      20, and 30 days; however, 18th- and 19-GD kidneys were rejected (grade III) by 
      the tenth post-transplantation day. To explore the basis for the decreased 
      immunogenicity of 15th-GD kidneys, 20 adult W/F rats were divided into two 
      groups. Each animal in the first group received one FSH 15th-GD kidney implanted 
      under the kidney capsule.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Velasco, A L
AU  - Velasco AL
AD  - Department of Surgery, University of Minnesota, Minneapolis.
FAU - Hegre, O D
AU  - Hegre OD
LA  - eng
GR  - DK 32237/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/*immunology
MH  - Dendritic Cells/immunology
MH  - Female
MH  - Fetus/*immunology
MH  - Gestational Age
MH  - *Graft Rejection
MH  - Kidney/*embryology/immunology
MH  - Leukocytes/*immunology
MH  - Male
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred F344
MH  - Rats, Inbred WF
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - S0022346889000254 [pii]
AID - 10.1016/s0022-3468(89)80303-3 [doi]
PST - ppublish
SO  - J Pediatr Surg. 1989 Jan;24(1):59-63; discussion 63. doi: 
      10.1016/s0022-3468(89)80303-3.