PMID- 27240161
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20220311
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 100
DP  - 2016 Sep
TI  - Enhanced brain-derived neurotrophic factor delivery by ultrasound and 
      microbubbles promotes white matter repair after stroke.
PG  - 41-52
LID - S0142-9612(16)30201-0 [pii]
LID - 10.1016/j.biomaterials.2016.05.028 [doi]
AB  - Ultrasound-targeted microbubble destruction (UTMD) has been shown to be a 
      promising tool to deliver proteins to select body areas. This study aimed to 
      analyze whether UTMD was able to deliver brain-derived neurotrophic factor (BDNF) 
      to the brain, enhancing functional recovery and white matter repair, in an animal 
      model of subcortical stroke induced by endothelin (ET)-1. UTMD was used to 
      deliver BDNF to the brain 24 h after stroke. This technique was shown to be safe, 
      given there were no cases of hemorrhagic transformation or blood brain barrier 
      (BBB) leakage. UTMD treatment was associated with increased brain BDNF levels at 
      4 h after administration. Targeted ultrasound delivery of BDNF improved 
      functional recovery associated with fiber tract connectivity restoration, 
      increasing oligodendrocyte markers and remyelination compared to BDNF alone 
      administration in an experimental animal model of white matter injury.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Rodriguez-Frutos, Berta
AU  - Rodriguez-Frutos B
AD  - Department of Neurology and Stroke Center, Neuroscience and Cerebrovascular 
      Research Laboratory, La Paz University Hospital, Neuroscience Area of IdiPAZ 
      (Health Research Institute), Autonoma University of Madrid, Madrid, Spain.
FAU - Otero-Ortega, Laura
AU  - Otero-Ortega L
AD  - Department of Neurology and Stroke Center, Neuroscience and Cerebrovascular 
      Research Laboratory, La Paz University Hospital, Neuroscience Area of IdiPAZ 
      (Health Research Institute), Autonoma University of Madrid, Madrid, Spain.
FAU - Ramos-Cejudo, Jaime
AU  - Ramos-Cejudo J
AD  - Department of Neurology and Stroke Center, Neuroscience and Cerebrovascular 
      Research Laboratory, La Paz University Hospital, Neuroscience Area of IdiPAZ 
      (Health Research Institute), Autonoma University of Madrid, Madrid, Spain.
FAU - Martinez-Sanchez, Patricia
AU  - Martinez-Sanchez P
AD  - Department of Neurology and Stroke Center, Neuroscience and Cerebrovascular 
      Research Laboratory, La Paz University Hospital, Neuroscience Area of IdiPAZ 
      (Health Research Institute), Autonoma University of Madrid, Madrid, Spain.
FAU - Barahona-Sanz, Ines
AU  - Barahona-Sanz I
AD  - Department of Neurology and Stroke Center, Neuroscience and Cerebrovascular 
      Research Laboratory, La Paz University Hospital, Neuroscience Area of IdiPAZ 
      (Health Research Institute), Autonoma University of Madrid, Madrid, Spain.
FAU - Navarro-Hernanz, Teresa
AU  - Navarro-Hernanz T
AD  - Laboratory for Imaging and Spectroscopy by Magnetic Resonance LISMAR, Institute 
      of Biomedical Research Alberto Sols, CSIC-UAM, Madrid, Spain.
FAU - Gomez-de Frutos, Maria Del Carmen
AU  - Gomez-de Frutos Mdel C
AD  - Department of Neurology and Stroke Center, Neuroscience and Cerebrovascular 
      Research Laboratory, La Paz University Hospital, Neuroscience Area of IdiPAZ 
      (Health Research Institute), Autonoma University of Madrid, Madrid, Spain.
FAU - Diez-Tejedor, Exuperio
AU  - Diez-Tejedor E
AD  - Department of Neurology and Stroke Center, Neuroscience and Cerebrovascular 
      Research Laboratory, La Paz University Hospital, Neuroscience Area of IdiPAZ 
      (Health Research Institute), Autonoma University of Madrid, Madrid, Spain. 
      Electronic address: exuperio.diez@salud.madrid.org.
FAU - Gutierrez-Fernandez, Maria
AU  - Gutierrez-Fernandez M
AD  - Department of Neurology and Stroke Center, Neuroscience and Cerebrovascular 
      Research Laboratory, La Paz University Hospital, Neuroscience Area of IdiPAZ 
      (Health Research Institute), Autonoma University of Madrid, Madrid, Spain. 
      Electronic address: mgutierrezfernandez@salud.madrid.org.
LA  - eng
PT  - Journal Article
DEP - 20160521
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects/pathology
MH  - Brain-Derived Neurotrophic Factor/*administration & 
      dosage/pharmacokinetics/therapeutic use
MH  - Cell Line
MH  - Drug Delivery Systems/*methods
MH  - Male
MH  - *Microbubbles
MH  - Oligodendroglia/drug effects/pathology
MH  - Rats, Sprague-Dawley
MH  - Stroke/*drug therapy/pathology
MH  - Ultrasonic Waves
MH  - Ultrasonics/*methods
MH  - White Matter/*drug effects/pathology
OTO - NOTNLM
OT  - BDNF
OT  - Brain repair
OT  - Microbubbles
OT  - Subcortical stroke
OT  - Ultrasound
OT  - White matter injury
EDAT- 2016/05/31 06:00
MHDA- 2017/12/13 06:00
CRDT- 2016/05/31 06:00
PHST- 2015/12/11 00:00 [received]
PHST- 2016/05/04 00:00 [revised]
PHST- 2016/05/17 00:00 [accepted]
PHST- 2016/05/31 06:00 [entrez]
PHST- 2016/05/31 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
AID - S0142-9612(16)30201-0 [pii]
AID - 10.1016/j.biomaterials.2016.05.028 [doi]
PST - ppublish
SO  - Biomaterials. 2016 Sep;100:41-52. doi: 10.1016/j.biomaterials.2016.05.028. Epub 
      2016 May 21.