PMID- 27240551
OWN - NLM
STAT- MEDLINE
DCOM- 20170406
LR  - 20221207
IS  - 1348-0421 (Electronic)
IS  - 0385-5600 (Linking)
VI  - 60
IP  - 7
DP  - 2016 Jul
TI  - Therapeutic effect of tyndallized Lactobacillus rhamnosus IDCC 3201 on atopic 
      dermatitis mediated by down-regulation of immunoglobulin E in NC/Nga mice.
PG  - 468-76
LID - 10.1111/1348-0421.12390 [doi]
AB  - The therapeutic effect of oral administration of Lactobacillus rhamnosus IDCC 
      3201 tyndallizate (RHT3201) on atopic dermatitis (AD)-like skin lesions in NC/Nga 
      mice were investigated. After induction of dermatitis in NC/Nga mice with 
      house-dust mite extract, each group was fed RHT3201 with 1 x 10(8) , 1 x 10(9) , 
      or 1 x 10(10) cells orally once a day for 8 weeks. Dermatitis scores and 
      frequency of scratching were improved by oral feeding with RHT3201. In contrast 
      to the control group, RHT3201-fed mice showed significantly down-regulated mast 
      cell numbers and serum immunoglobulin E (IgE) concentrations had significantly 
      less IL4 in their axillary lymph node cells. The therapeutic effect of RHT3201 
      was found to be dose-dependent. These findings indicate that RHT3201 has 
      potential for treating AD.
CI  - (c) 2016 The Societies and John Wiley & Sons Australia, Ltd.
FAU - Lee, Seung-Hun
AU  - Lee SH
AD  - Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 
      18449.
AD  - Department of Biotechnology and Bioengineering, Konkuk University, 120, 
      Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
FAU - Yoon, Jong-Min
AU  - Yoon JM
AD  - Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 
      18449.
FAU - Kim, Young-Hoo
AU  - Kim YH
AD  - Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 
      18449.
FAU - Jeong, Dong-Gu
AU  - Jeong DG
AD  - Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 
      18449.
FAU - Park, Soobong
AU  - Park S
AD  - Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 
      18449.
FAU - Kang, Dae-Jung
AU  - Kang DJ
AD  - Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 
      18449.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
EIN - Microbiol Immunol. 2016 Aug;60(8):570. PMID: 27543721
MH  - Administration, Oral
MH  - Animals
MH  - Biopsy
MH  - Cytokines/blood/metabolism
MH  - Dermatitis, Atopic/diagnosis/*immunology/therapy
MH  - Disease Models, Animal
MH  - Female
MH  - Immunoglobulin E/blood/*immunology
MH  - Immunotherapy
MH  - Lacticaseibacillus rhamnosus/*immunology/ultrastructure
MH  - Lymph Nodes/immunology/metabolism
MH  - Mice
MH  - Phenotype
MH  - Probiotics/*administration & dosage
OTO - NOTNLM
OT  - Lactobacillus rhamnosus
OT  - atopic dermatitis
OT  - immunoglobulin E
OT  - tyndallization
EDAT- 2016/06/01 06:00
MHDA- 2017/04/07 06:00
CRDT- 2016/06/01 06:00
PHST- 2016/01/26 00:00 [received]
PHST- 2016/05/20 00:00 [revised]
PHST- 2016/05/24 00:00 [accepted]
PHST- 2016/06/01 06:00 [entrez]
PHST- 2016/06/01 06:00 [pubmed]
PHST- 2017/04/07 06:00 [medline]
AID - 10.1111/1348-0421.12390 [doi]
PST - ppublish
SO  - Microbiol Immunol. 2016 Jul;60(7):468-76. doi: 10.1111/1348-0421.12390.