PMID- 2724072
OWN - NLM
STAT- MEDLINE
DCOM- 19890628
LR  - 20200220
IS  - 0894-9255 (Print)
IS  - 0894-9255 (Linking)
VI  - 2
IP  - 3
DP  - 1989
TI  - Frequent infection with human T-cell lymphotropic virus type I in patients with 
      AIDS but not in carriers of human immunodeficiency virus type 1.
PG  - 272-6
AB  - Antibody to human T-cell lymphotropic virus type I (HTLV-I) was measured in 49 
      Japanese patients (48 with hemophilia) infected with human immunodeficiency virus 
      type 1 (HIV-1) and in 18 hemophiliacs who were not infected with HIV-1, by use of 
      an enzyme-linked immunosorbent assay (ELISA). The antigen used was a gag-env 
      hybrid protein constructed in vitro and expressed in Escherichia coli. This assay 
      detected a specific antibody against HTLV-I. Four of the 18 HIV-1-negative 
      hemophiliacs (22%) were positive for anti-HTLV-I antibody; their geometric mean 
      titer was 951 U/ml. Seven of the 12 patients (58%) with acquired immune 
      deficiency syndrome (AIDS) were positive for anti-HTLV-I antibody, and 8 of 35 
      HIV-1 + AIDS-free carriers (23%) were positive. The difference between the 
      prevalence of HTLV-I infection in the two groups was statistically significant (p 
      less than 0.0297). The geometric mean titer of antibody in the patients with AIDS 
      was 318 U/ml and that for the HIV-1 + AIDS-free carriers was 1,496 U/ml. These 
      findings suggest that HTLV-I infection could be one of the factors in the 
      development of AIDS in individuals infected with HIV-I.
FAU - Hattori, T
AU  - Hattori T
AD  - Second Department of Internal Medicine, Faculty of Medicine, Kumamoto University 
      Medical School, Japan.
FAU - Koito, A
AU  - Koito A
FAU - Takatsuki, K
AU  - Takatsuki K
FAU - Ikematsu, S
AU  - Ikematsu S
FAU - Matsuda, J
AU  - Matsuda J
FAU - Mori, H
AU  - Mori H
FAU - Fukui, M
AU  - Fukui M
FAU - Akashi, K
AU  - Akashi K
FAU - Matsumoto, K
AU  - Matsumoto K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr (1988)
JT  - Journal of acquired immune deficiency syndromes
JID - 8812597
RN  - 0 (HTLV-I Antibodies)
RN  - 0 (HTLV-I Antigens)
RN  - 0 (Retroviridae Proteins)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
EIN - J Acquir Immune Defic Syndr 1989;2(6):604
MH  - AIDS-Related Complex/complications
MH  - Acquired Immunodeficiency Syndrome/*complications
MH  - Adult
MH  - Blotting, Western
MH  - Enzyme-Linked Immunosorbent Assay
MH  - *HIV Seropositivity
MH  - HTLV-I Antibodies/*analysis
MH  - HTLV-I Antigens/analysis
MH  - HTLV-I Infections/*complications
MH  - Hemophilia A/blood
MH  - Hemophilia B/blood
MH  - Humans
MH  - Middle Aged
MH  - Retroviridae Proteins/analysis
MH  - Viral Envelope Proteins/analysis
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
PST - ppublish
SO  - J Acquir Immune Defic Syndr (1988). 1989;2(3):272-6.