PMID- 27240834
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20220311
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 169
IP  - 4
DP  - 2016
TI  - Component-Resolved Diagnosis of Peanut Allergy and Its Possible Origins of 
      Sensitization in China.
PG  - 241-8
LID - 10.1159/000446156 [doi]
AB  - BACKGROUND: Clinical and immunological characteristics of food allergies vary 
      depending on geographic regions. Little is known about peanut allergy in China. 
      The aim of this study was to investigate the peanut sensitization profile in 
      China. METHODS: Thirty-eight participants with immunoglobulin E (IgE)-positive 
      responses to peanuts (peanut-sensitized) were included in our study, and clinical 
      characteristics were evaluated. Total and specific IgE reactivity against 
      peanuts, other plant-derived foods, pollens, and related allergen components were 
      determined. RESULTS: Eighteen patients were symptomatic when exposed to peanuts. 
      The majority of them presented with systemic reactions. More than half of the 
      peanut-sensitized subjects also suffered from mugwort pollinosis and peach 
      allergy. In patients with both peanut and peach allergies, reactions to peanuts 
      were the same as or severer than those to peaches. Positivity rates of IgE 
      response to rAra h 1-3, 8, and 9 in the peanut allergy group were 5.6, 11.1, 5.6, 
      22.2, and 83.3%, respectively. 66.7% (12/18) of the peanut-allergic patients were 
      monosensitized to rAra h 9. Anti-nArt v 3 [mugwort nonspecific lipid transfer 
      protein (nsLTP)] IgE positivity in the peanut allergy group was significantly 
      higher than that in the asymptomatic peanut-sensitized group. In Ara h 9 (peanut 
      nsLTP)-sensitized patients with mugwort pollinosis, anti-nArt v 3 IgE levels were 
      remarkably higher than anti-rAra h 9 (peanut nsLTP) IgE levels as well as 
      anti-Pru p 3 (peach nsLTP) IgE levels. CONCLUSIONS: Ara h 9 was the major 
      allergen of peanut, and Ara h 9 monosensitization was the most common peanut 
      sensitization pattern in our population. Furthermore, there was a strong 
      correlation between peanut sensitization and mugwort pollinosis, as well as peach 
      allergy, in our country.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Ma, Shikun
AU  - Ma S
AD  - Department of Allergy, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, China.
FAU - Nie, Li
AU  - Nie L
FAU - Li, Hong
AU  - Li H
FAU - Wang, Ruiqi
AU  - Wang R
FAU - Yin, Jia
AU  - Yin J
LA  - eng
PT  - Journal Article
DEP - 20160531
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/immunology
MH  - Antigens, Plant/immunology
MH  - Arachis/immunology
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunization
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Peanut Hypersensitivity/*diagnosis/*immunology
MH  - Phenotype
MH  - Young Adult
EDAT- 2016/06/01 06:00
MHDA- 2017/02/24 06:00
CRDT- 2016/06/01 06:00
PHST- 2015/11/02 00:00 [received]
PHST- 2016/04/11 00:00 [accepted]
PHST- 2016/06/01 06:00 [entrez]
PHST- 2016/06/01 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
AID - 000446156 [pii]
AID - 10.1159/000446156 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2016;169(4):241-8. doi: 10.1159/000446156. Epub 2016 
      May 31.