PMID- 27240860
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20181113
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Linking)
VI  - 68
IP  - 9
DP  - 2016 Oct
TI  - Killer cell immunoglobulin-like receptor and human leukocyte antigen gene 
      profiles in a cohort of HIV-infected Mexican Mestizos.
PG  - 703-17
LID - 10.1007/s00251-016-0920-3 [doi]
AB  - Killer cell immunoglobulin-like receptors (KIRs) represent the most polymorphic 
      genes responsible for natural killer cell function, while human leukocyte antigen 
      (HLA) class I molecules define and restrict cytotoxic T lymphocyte responses. 
      Specific KIR, HLA, or KIR-HLA combinations have been implicated in the outcome of 
      human immunodeficiency virus (HIV) disease. The remarkable polymorphism of KIR 
      and HLA genes warrants descriptive gene frequency studies in different 
      populations, as well as their impact on HIV disease progression in different 
      immunogenetic contexts. We report KIR and HLA class I gene profiles of 511 
      unrelated HIV-infected Mexican Mestizo individuals from 18 states for whom 
      genetic ancestry proportions were assessed. KIR and HLA gene profiles were 
      compared between individuals from the north and central-south regions of the 
      country and between individuals with higher European (EUR) or Amerindian (AMI) 
      genetic ancestry component. A total of 65 KIR genotypes were observed, 11 
      harboring novel KIR gene combinations. A total of 164 HLA alleles were observed: 
      43 HLA-A, 87 HLA-B, and 34 HLA-C. Differences in the distribution of 12 HLA 
      alleles were observed between individuals with higher AMI or EUR ancestry 
      components (p < 0.05, q < 0.2). After correcting for genetic ancestry, only 
      individual HLA alleles were associated with HIV disease progression, including a 
      novel association with A*02:06, an Amerindian HLA allele associated with lower 
      CD4+ T cell counts. No KIR effects were significant. Our results highlight the 
      advantages of considering a detailed genetic stratification within populations 
      when studying genetic profiles that could be implicated in disease-association 
      studies.
FAU - Garrido-Rodriguez, Daniela
AU  - Garrido-Rodriguez D
AD  - National Institute of Respiratory Diseases, Centre for Research in Infectious 
      Diseases, Calzada de Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico.
FAU - Avila-Rios, Santiago
AU  - Avila-Rios S
AD  - National Institute of Respiratory Diseases, Centre for Research in Infectious 
      Diseases, Calzada de Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico.
FAU - Garcia-Morales, Claudia
AU  - Garcia-Morales C
AD  - National Institute of Respiratory Diseases, Centre for Research in Infectious 
      Diseases, Calzada de Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico.
FAU - Valenzuela-Ponce, Humberto
AU  - Valenzuela-Ponce H
AD  - National Institute of Respiratory Diseases, Centre for Research in Infectious 
      Diseases, Calzada de Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico.
FAU - Ormsby, Christopher
AU  - Ormsby C
AD  - National Institute of Respiratory Diseases, Centre for Research in Infectious 
      Diseases, Calzada de Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico.
FAU - Reyes-Gopar, Helena
AU  - Reyes-Gopar H
AD  - National Institute of Respiratory Diseases, Centre for Research in Infectious 
      Diseases, Calzada de Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico.
FAU - Fernandez-Lopez, Juan Carlos
AU  - Fernandez-Lopez JC
AD  - National Institute of Genomic Medicine, Periferico Sur 4809, Arenal Tepepan, 
      14610, Mexico City, Mexico.
FAU - Reyes-Teran, Gustavo
AU  - Reyes-Teran G
AD  - National Institute of Respiratory Diseases, Centre for Research in Infectious 
      Diseases, Calzada de Tlalpan 4502, Col. Seccion XVI, 14080, Mexico City, Mexico. 
      gustavo.reyesteran@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160530
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - CD4-Positive T-Lymphocytes
MH  - Disease Progression
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HIV Infections/*genetics/*immunology/virology
MH  - HIV-1/*genetics
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Killer Cells, Natural/metabolism
MH  - Male
MH  - Mexican Americans/*genetics
MH  - Mexico
MH  - Polymorphism, Genetic/*genetics
MH  - Receptors, KIR/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Ancestry genetic proportions
OT  - HLA
OT  - Human immunodeficiency virus
OT  - Immunogenetics
OT  - KIR
OT  - Mexican Mestizo
EDAT- 2016/06/01 06:00
MHDA- 2017/05/13 06:00
CRDT- 2016/06/01 06:00
PHST- 2016/02/08 00:00 [received]
PHST- 2016/05/21 00:00 [accepted]
PHST- 2016/06/01 06:00 [entrez]
PHST- 2016/06/01 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
AID - 10.1007/s00251-016-0920-3 [pii]
AID - 10.1007/s00251-016-0920-3 [doi]
PST - ppublish
SO  - Immunogenetics. 2016 Oct;68(9):703-17. doi: 10.1007/s00251-016-0920-3. Epub 2016 
      May 30.