PMID- 27240861
OWN - NLM
STAT- MEDLINE
DCOM- 20170418
LR  - 20190221
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 24
IP  - 7
DP  - 2016 Oct
TI  - Podoplanin Expression Is Correlated With the Progression of Chronic Discoid Lupus 
      Erythematosus to Lip Squamous Cell Carcinoma.
PG  - 595-9
LID - 10.1177/1066896916652220 [doi]
AB  - Chronic lip discoid lupus erythematosus (DLE) is a potentially malignant disorder 
      that can develop into lip squamous cell carcinoma (LSCC). Podoplanin is a 
      specific marker for lymphatic endothelial cells and plays a role in cancer 
      progression. The objective of this study was to determine the immunoexpression of 
      podoplanin in samples of patients with DLE and its correlation with the risk of 
      progression to LSCC. In a retrospective study, podoplanin expression was 
      determined using immunohistochemistry in samples from 52 patients with DLE, 
      including 44 patients with untransformed DLE and 8 patients with malignant 
      transformed DLE. Ten samples of normal oral mucosa and 10 samples of LSCC were 
      used as normal and cancer controls, respectively. The results showed that 
      podoplanin expression was observed in 12 of 44 (27.3%) patients with 
      untransformed DLE and in 7 of 8 (87.5%) patients with transformed DLE (P = .002). 
      Podoplanin was not expressed in normal oral mucosa, but it was overexpressed in 
      all of the 10 patients with LSCC. Regression analysis revealed that podoplanin 
      expression was significantly associated with an 18.67-fold increase in the risk 
      of malignant progression (95% confidence interval = 2.07-168.10; P = .009). In 
      summary, podoplanin expression is significantly associated with malignant 
      transformation of DLE into LSCC. Thus, podoplanin expression may identify a 
      subgroup with a high risk of malignant progression of DLE.
CI  - (c) The Author(s) 2016.
FAU - Gao, Xing
AU  - Gao X
AD  - XiangYa Hospital, Central South University, Changsha, Hunan, China.
FAU - Ma, Liwei
AU  - Ma L
AD  - Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Zhou, Zengtong
AU  - Zhou Z
AD  - Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Jian, Xinchun
AU  - Jian X
AD  - XiangYa Hospital, Central South University, Changsha, Hunan, China.
FAU - Liu, Wei
AU  - Liu W
AD  - Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China jianxinchun@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20160529
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (PDPN protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Squamous Cell/metabolism/*pathology
MH  - Cell Transformation, Neoplastic/metabolism/pathology
MH  - Disease Progression
MH  - Female
MH  - Head and Neck Neoplasms/metabolism/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Lip Neoplasms/metabolism/*pathology
MH  - Lupus Erythematosus, Discoid/metabolism/*pathology
MH  - Male
MH  - Membrane Glycoproteins/analysis/*biosynthesis
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
OTO - NOTNLM
OT  - discoid lupus erythematosus
OT  - lip squamous cell carcinoma
OT  - podoplanin
EDAT- 2016/06/01 06:00
MHDA- 2017/04/19 06:00
CRDT- 2016/06/01 06:00
PHST- 2016/06/01 06:00 [entrez]
PHST- 2016/06/01 06:00 [pubmed]
PHST- 2017/04/19 06:00 [medline]
AID - 1066896916652220 [pii]
AID - 10.1177/1066896916652220 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2016 Oct;24(7):595-9. doi: 10.1177/1066896916652220. Epub 2016 
      May 29.