PMID- 27241147
OWN - NLM
STAT- MEDLINE
DCOM- 20160930
LR  - 20181202
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 41
IP  - 4
DP  - 2016 Apr
TI  - [Pathologic characteristics of bone marrow for 
CD5 positive small B cell 
      lymphoma].
PG  - 374-9
LID - 10.11817/j.issn.1672-7347.2016.04.006 [doi]
AB  - OBJECTIVE: To study the pathologic characteristics of bone marrow for CD5 
      positive small B cell lymphoma (SBL).
 METHODS: The pathologic profiles of 92 
      patients with CD5 positive SBL were retrospectively analyzed. The morphologic and 
      immunophenotypic features were analyzed by flow cytometry and 
      immunohistochemistry. IgH/CCND1 was examined by fluorescence in situ 
      hybridization (FISH).
 RESULTS: A total of 92 patients with CD5 positive SBL were 
      enrolled in this study, including 56 (60.9%) chronic lymphocytic leukemia /small 
      lymphocytic lymphoma (CLL/SLL), 23 (25.0%) mantle cell lymphoma (MCL) and 13 
      other SBL (14.1%). Among the 13 other cases, 5, 4 and 4 cases were follicular 
      lymphoma (FL), lymphoplasmacytic lymphoma (LPL) and splenic marginal zone 
      lymphoma (SMZL), respectively. The frequency of patterns for bone marrow 
      infiltration was as follow: diffuse pattern (19/92), mixed pattern (15/92), 
      nodular pattern (9/92), interstitial pattern (8/92), and intrasinusodial pattern 
      (2/92). All patients expressed CD19, CD20 and CD5. According to the 
      immunophenotypic score system, all the CLL patients had 4-5 scores, while SMCL 
      and other SBL patients had less than 3 scores. For the other SBL patients, 5 FL 
      expressed CD10, while 3 FL, 1 LPL and 3 SMZL expressed CD23. There was a 
      significant difference in the expression of CD23, sIgM, FMC7, CD11C and CD22 
      between the CLL and MCL groups (P<0.01). All 23 MCL patients expressed cyclin D1 
      and showed IgH/CCND1 gene translocation by FISH detection.
 CONCLUSION: CD5 
      positive SBL includes a variety of types of lymphoma. Patterns of bone marrow for 
      CD5 positive SBL are diversity. Immunophenotypic analysis by flow cytometry is 
      essential in the diagnosis and differential diagnosis of CD5 positive SBL, 
      especially for CLL.
FAU - Peng, Shusong
AU  - Peng S
AD  - Department of Pathology, Shenzhen People's Hospital, Shenzhen Guangdong 518020, 
      China.
FAU - Zhu, Fuqiang
AU  - Zhu F
AD  - Department of Pathology, Shenzhen People's Hospital, Shenzhen Guangdong 518020, 
      China.
FAU - You, Sijing
AU  - You S
AD  - Department of Pathology, Shenzhen People's Hospital, Shenzhen Guangdong 518020, 
      China.
FAU - Gong, Minna
AU  - Gong M
AD  - Department of Pathology, Shenzhen People's Hospital, Shenzhen Guangdong 518020, 
      China.
FAU - Wen, Zhonglian
AU  - Wen Z
AD  - Department of Pathology, Shenzhen People's Hospital, Shenzhen Guangdong 518020, 
      China.
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (CD5 Antigens)
RN  - 0 (IGH-CCND1 fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Bone Marrow/*pathology
MH  - CD5 Antigens/*metabolism
MH  - Diagnosis, Differential
MH  - Flow Cytometry
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis
MH  - Lymphoma, B-Cell/*diagnosis
MH  - Lymphoma, Follicular/diagnosis
MH  - Lymphoma, Mantle-Cell/diagnosis
MH  - Oncogene Proteins, Fusion/metabolism
MH  - Retrospective Studies
MH  - Splenic Neoplasms/diagnosis
EDAT- 2016/06/01 06:00
MHDA- 2016/10/01 06:00
CRDT- 2016/06/01 06:00
PHST- 2016/06/01 06:00 [entrez]
PHST- 2016/06/01 06:00 [pubmed]
PHST- 2016/10/01 06:00 [medline]
AID - 10.11817/j.issn.1672-7347.2016.04.006 [doi]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Apr;41(4):374-9. doi: 
      10.11817/j.issn.1672-7347.2016.04.006.