PMID- 27242514
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160531
LR  - 20200929
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 8
DP  - 2016
TI  - EPA/DHA and Vitamin A Supplementation Improves Spatial Memory and Alleviates the 
      Age-related Decrease in Hippocampal RXRgamma and Kinase Expression in Rats.
PG  - 103
LID - 10.3389/fnagi.2016.00103 [doi]
LID - 103
AB  - Studies suggest that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and 
      vitamin A are critical to delay aged-related cognitive decline. These nutrients 
      regulate gene expression in the brain by binding to nuclear receptors such as the 
      retinoid X receptors (RXRs) and the retinoic acid receptors (RARs). Moreover, 
      EPA/DHA and retinoids activate notably kinase signaling pathways such as AKT or 
      MAPK, which includes ERK1/2. This suggests that these nutrients may modulate 
      brain function in a similar way. Therefore, we investigated in middle-aged rats 
      the behavioral and molecular effects of supplementations with EPA/DHA and vitamin 
      A alone or combined. 18-month-old rats exhibited reference and working memory 
      deficits in the Morris water maze, associated with a decrease in serum vitamin A 
      and hippocampal EPA/DHA contents. RARalpha, RXRbeta, and RXRgamma mRNA expression and 
      CAMKII, AKT, ERK1/2 expression were decreased in the hippocampus of middle-aged 
      rats. A combined EPA/DHA and vitamin A supplementation had a beneficial additive 
      effect on reference memory but not in working memory in middle-aged rats, 
      associated with an alleviation of the age-related decrease in RXRgamma, CAMKII, AKT, 
      and ERK1 expression in the hippocampus. This study provides a new combined 
      nutritional strategy to delay brain aging.
FAU - Letondor, Anne
AU  - Letondor A
AD  - Universite de Bordeaux, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, 
      France; INRA, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, France; 
      Bordeaux INP, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, France; 
      ITERG, Institut des Corps GrasPessac, France.
FAU - Buaud, Benjamin
AU  - Buaud B
AD  - ITERG, Institut des Corps Gras Pessac, France.
FAU - Vaysse, Carole
AU  - Vaysse C
AD  - ITERG, Institut des Corps Gras Pessac, France.
FAU - Richard, Emmanuel
AU  - Richard E
AD  - INSERM, Biotherapie des Maladies Genetiques Inflammatoires et Cancers, U1035 
      Bordeaux, France.
FAU - Laye, Sophie
AU  - Laye S
AD  - Universite de Bordeaux, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, 
      France; INRA, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, France.
FAU - Pallet, Veronique
AU  - Pallet V
AD  - Universite de Bordeaux, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, 
      France; INRA, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, France; 
      Bordeaux INP, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, France.
FAU - Alfos, Serge
AU  - Alfos S
AD  - Universite de Bordeaux, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, 
      France; INRA, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, France; 
      Bordeaux INP, Nutrition et Neurobiologie Integree, UMR 1286Bordeaux, France.
LA  - eng
PT  - Journal Article
DEP - 20160509
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC4860397
OTO - NOTNLM
OT  - hippocampus
OT  - kinases
OT  - n-3 long-chain PUFA
OT  - retinoid receptors
OT  - spatial memory
OT  - vitamin A
EDAT- 2016/06/01 06:00
MHDA- 2016/06/01 06:01
PMCR- 2016/01/01
CRDT- 2016/06/01 06:00
PHST- 2015/12/17 00:00 [received]
PHST- 2016/04/22 00:00 [accepted]
PHST- 2016/06/01 06:00 [entrez]
PHST- 2016/06/01 06:00 [pubmed]
PHST- 2016/06/01 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2016.00103 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2016 May 9;8:103. doi: 10.3389/fnagi.2016.00103. 
      eCollection 2016.