PMID- 27242654
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160531
LR  - 20200929
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 7
DP  - 2016
TI  - BDNF Genotype Interacts with Motor Function to Influence Rehabilitation 
      Responsiveness Poststroke.
PG  - 69
LID - 10.3389/fneur.2016.00069 [doi]
LID - 69
AB  - BACKGROUND: Persistent motor impairment is common but highly heterogeneous 
      poststroke. Genetic polymorphisms, including those identified on the 
      brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) genes, may 
      contribute to this variability by limiting the capacity for use-dependent 
      neuroplasticity, and hence rehabilitation responsiveness. OBJECTIVE: To determine 
      whether BDNF and APOE genotypes influence motor improvement facilitated by 
      poststroke upper-limb rehabilitation. METHODS: BDNF-Val66Met and APOE isoform 
      genotypes were determined using leukocyte DNA for 55 community-dwelling patients 
      2-123 months poststroke. All patients completed a dose-matched upper-limb 
      rehabilitation program of either Wii-based Movement Therapy or Constraint-induced 
      Movement Therapy. Upper-limb motor function was assessed pre- and post-therapy 
      using a suite of functional measures. RESULTS: Motor function improved for all 
      patients post-therapy, with no difference between therapy groups. In the pooled 
      data, there was no significant effect of BDNF or APOE genotype on motor function 
      at baseline, or following the intervention. However, a significant interaction 
      between the level of residual motor function and BDNF genotype was identified 
      (p = 0.029), whereby post-therapy improvement was significantly less for Met 
      allele carriers with moderate and high, but not low motor function. There was no 
      significant association between APOE genotype and therapy outcomes. CONCLUSION: 
      This study identified a novel interaction between the BDNF-Val66Met polymorphism, 
      motor-function status, and the magnitude of improvement with rehabilitation in 
      chronic stroke. This polymorphism does not preclude, but may reduce, the 
      magnitude of motor improvement with therapy, particularly for patients with 
      higher, but not lower residual motor function. BDNF genotype should be considered 
      in the design and interpretation of clinical trials.
FAU - Shiner, Christine T
AU  - Shiner CT
AD  - Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical 
      Sciences, University of New South Wales, Sydney, NSW, Australia.
FAU - Pierce, Kerrie D
AU  - Pierce KD
AD  - Neuroscience Research Australia , Sydney, NSW , Australia.
FAU - Thompson-Butel, Angelica G
AU  - Thompson-Butel AG
AD  - Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical 
      Sciences, University of New South Wales, Sydney, NSW, Australia.
FAU - Trinh, Terry
AU  - Trinh T
AD  - Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical 
      Sciences, University of New South Wales, Sydney, NSW, Australia.
FAU - Schofield, Peter R
AU  - Schofield PR
AD  - Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical 
      Sciences, University of New South Wales, Sydney, NSW, Australia.
FAU - McNulty, Penelope A
AU  - McNulty PA
AD  - Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical 
      Sciences, University of New South Wales, Sydney, NSW, Australia.
LA  - eng
PT  - Journal Article
DEP - 20160517
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC4868962
OTO - NOTNLM
OT  - apolipoprotein E
OT  - brain-derived neurotrophic factor
OT  - motor rehabilitation
OT  - stroke genetics
OT  - upper limb
EDAT- 2016/06/01 06:00
MHDA- 2016/06/01 06:01
PMCR- 2016/05/17
CRDT- 2016/06/01 06:00
PHST- 2016/03/04 00:00 [received]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/06/01 06:00 [entrez]
PHST- 2016/06/01 06:00 [pubmed]
PHST- 2016/06/01 06:01 [medline]
PHST- 2016/05/17 00:00 [pmc-release]
AID - 10.3389/fneur.2016.00069 [doi]
PST - epublish
SO  - Front Neurol. 2016 May 17;7:69. doi: 10.3389/fneur.2016.00069. eCollection 2016.