PMID- 27243039
OWN - NLM
STAT- MEDLINE
DCOM- 20170316
LR  - 20181113
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2016
DP  - 2016
TI  - Clinical Relevance of HLA Gene Variants in HBV Infection.
PG  - 9069375
LID - 10.1155/2016/9069375 [doi]
LID - 9069375
AB  - Host gene variants may influence the natural history of hepatitis B virus (HBV) 
      infection. The human leukocyte antigen (HLA) system, the major histocompatibility 
      complex (MHC) in humans, is one of the most important host factors that are 
      correlated with the clinical course of HBV infection. Genome-wide association 
      studies (GWASs) have shown that single nucleotide polymorphisms (SNPs) near 
      certain HLA gene loci are strongly associated with not only persistent HBV 
      infection but also spontaneous HBV clearance and seroconversion, disease 
      progression, and the development of liver cirrhosis and HBV-related 
      hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB). These variations 
      also influence the efficacy of interferon (IFN) and nucleot(s)ide analogue (NA) 
      treatment and response to HBV vaccines. Meanwhile, discrepant conclusions were 
      reached with different patient cohorts. It is therefore essential to identify the 
      associations of specific HLA allele variants with disease progression and viral 
      clearance in chronic HBV infection among different ethnic populations. A better 
      understanding of HLA polymorphism relevance in HBV infection outcome would enable 
      us to elucidate the roles of HLA SNPs in the pathogenesis and clearance of HBV in 
      different areas and ethnic groups, to improve strategies for the prevention and 
      treatment of chronic HBV infection.
FAU - Wang, Li
AU  - Wang L
AD  - Infectious Disease Hospital of Yantai, 62 Huanshan Road, Zhifu District, Yantai, 
      Shandong 264001, China.
FAU - Zou, Zhi-Qiang
AU  - Zou ZQ
AD  - Infectious Disease Hospital of Yantai, 62 Huanshan Road, Zhifu District, Yantai, 
      Shandong 264001, China.
FAU - Wang, Kai
AU  - Wang K
AD  - Hepatology Department, Qilu Hospital of Shandong University, 44 Wenhua West Road, 
      Lixia District, Jinan, Shandong 250012, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160508
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Antiviral Agents)
RN  - 0 (HLA Antigens)
RN  - 0 (Hepatitis B Vaccines)
RN  - 0 (Hepatitis B e Antigens)
RN  - 0 (Interferon-alpha)
SB  - IM
MH  - Antiviral Agents/pharmacology/therapeutic use
MH  - Carcinoma, Hepatocellular/etiology
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - HLA Antigens/*genetics/*immunology
MH  - Hepatitis B/complications/*genetics/*immunology/virology
MH  - Hepatitis B Vaccines/immunology
MH  - Hepatitis B e Antigens/immunology
MH  - Hepatitis B virus/*immunology
MH  - Host-Pathogen Interactions/*genetics/*immunology
MH  - Humans
MH  - Interferon-alpha/pharmacology/therapeutic use
MH  - Liver Cirrhosis/etiology
MH  - Liver Neoplasms/etiology
MH  - Risk
MH  - Treatment Outcome
MH  - Vaccination
MH  - Viral Load
PMC - PMC4875979
EDAT- 2016/06/01 06:00
MHDA- 2017/03/17 06:00
PMCR- 2016/05/08
CRDT- 2016/06/01 06:00
PHST- 2016/02/22 00:00 [received]
PHST- 2016/04/14 00:00 [accepted]
PHST- 2016/06/01 06:00 [entrez]
PHST- 2016/06/01 06:00 [pubmed]
PHST- 2017/03/17 06:00 [medline]
PHST- 2016/05/08 00:00 [pmc-release]
AID - 10.1155/2016/9069375 [doi]
PST - ppublish
SO  - J Immunol Res. 2016;2016:9069375. doi: 10.1155/2016/9069375. Epub 2016 May 8.