PMID- 27243229
OWN - NLM
STAT- MEDLINE
DCOM- 20190301
LR  - 20220410
IS  - 2005-6648 (Electronic)
IS  - 1226-3303 (Print)
IS  - 1226-3303 (Linking)
VI  - 33
IP  - 1
DP  - 2018 Jan
TI  - Disease-specific impairment of the quality of life in adult patients with chronic 
      spontaneous urticaria.
PG  - 185-192
LID - 10.3904/kjim.2015.195 [doi]
AB  - BACKGROUND/AIMS: Chronic urticaria (CU) is a common skin disorder characterized 
      by wheals and pruritus lasting more than 6 weeks. Due to its long duration and 
      changeable symptoms, the quality of life (QOL) of patients with CU can be 
      impaired substantially. We evaluated the CU-QOL, a previously validated 
      CU-specific QOL measure, and investigated factors influencing QOL in chronic 
      spontaneous urticaria (CSU) patients. METHODS: A hospital-based cross-sectional 
      study was performed on 390 adult patients diagnosed with CSU from March 2009 to 
      December 2012 at the Allergy and Clinical Immunology Clinic at Ajou University 
      Hospital. The CU-QOL questionnaire, urticaria activity score (UAS), combined 
      angioedema, and serum total immunoglobulin E (IgE) levels were investigated. 
      RESULTS: The average CU-QOL score obtained from the questionnaire was 70.6 (of 
      100 points). The CU-QOL scores correlated significantly with the UAS, 
      particularly with the 15-point UAS (UAS-15; coefficient -0.532, p < 0.01) rather 
      than the 6-point UAS (-0.502, p < 0.01). The patients presenting with angioedema 
      and urticaria had poorer scores in the urticaria symptom domain than those with 
      urticaria alone (37.4 vs. 46.9, p = 0.004). Log-transformed serum total IgE 
      levels correlated significantly with CU-QOL (-0.131, p < 0.05). Multivariate 
      regression models indicated that severe CU (UAS-15 score >/= 13), log (total IgE), 
      and the presence of angioedema were significant predictors of impaired CU-QOL (< 
      85 points). CONCLUSIONS: CU has a substantial negative impact on QOL. The 
      assessment of UAS-15, total IgE, and the presence of angioedema can be useful to 
      predict QOL of the patients with CSU.
FAU - Choi, Won-Sun
AU  - Choi WS
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Lim, Eun-Soo
AU  - Lim ES
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Ban, Ga-Young
AU  - Ban GY
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Kim, Ji-Hye
AU  - Kim JH
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Shin, Yoo-Seob
AU  - Shin YS
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Park, Hae-Sim
AU  - Park HS
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
FAU - Ye, Young-Min
AU  - Ye YM
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, Korea.
LA  - eng
PT  - Journal Article
DEP - 20160601
PL  - Korea (South)
TA  - Korean J Intern Med
JT  - The Korean journal of internal medicine
JID - 8712418
SB  - IM
MH  - Adult
MH  - Angioedema/*complications
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Urticaria/*complications
MH  - Young Adult
PMC - PMC5768532
OTO - NOTNLM
OT  - Angioedema
OT  - Chronic
OT  - Immunoglobulin E
OT  - Quality of life
OT  - Urticaria
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2016/06/01 06:00
MHDA- 2019/03/02 06:00
PMCR- 2018/01/01
CRDT- 2016/06/01 06:00
PHST- 2015/06/29 00:00 [received]
PHST- 2015/08/24 00:00 [revised]
PHST- 2015/09/17 00:00 [accepted]
PHST- 2016/06/01 06:00 [pubmed]
PHST- 2019/03/02 06:00 [medline]
PHST- 2016/06/01 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - kjim.2015.195 [pii]
AID - kjim-2015-195 [pii]
AID - 10.3904/kjim.2015.195 [doi]
PST - ppublish
SO  - Korean J Intern Med. 2018 Jan;33(1):185-192. doi: 10.3904/kjim.2015.195. Epub 
      2016 Jun 1.