PMID- 27245075
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20211204
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 14
IP  - 1
DP  - 2016 May 31
TI  - mTOR inhibitors effects on regulatory T cells and on dendritic cells.
PG  - 152
LID - 10.1186/s12967-016-0916-7 [doi]
LID - 152
AB  - The mammalian target of rapamycin (mTOR), a cytoplasmic serine/threonine kinase, 
      represents a key biologic "switch" modulating cell metabolisms in response to 
      environmental signals and is now recognized as a central regulator of the immune 
      system. There is an increasing body of evidence supporting the hypothesis that 
      mTOR inhibitors exhibit several biological properties in addition to 
      immunosuppression, including anti-neoplastic effects, cardio-protective 
      activities, and an array of immunomodulatory actions facilitating the development 
      of an operational graft tolerance. The biological mechanisms explaining how mTOR 
      inhibition can enable a tolerogenic state are still largely unclear. The 
      induction of transplant tolerance might at the same time decrease rejection rate 
      and minimize immunosuppression-related side effects, leading to an improvement in 
      long-term graft outcome. In this scenario, T cell immunoregulation has been 
      defined as the hallmark of peripheral tolerance. Two main immunologic cell 
      populations have been reported to play a central role in this setting: regulatory 
      T cells (Tregs) and dendritic cells (DCs). In this review we focus on mTOR 
      inhibitors effects on Treg and DCs differentiation, activation, and function in 
      the transplantation setting.
FAU - Stallone, Giovanni
AU  - Stallone G
AD  - Nephrology, Dialysis and Tranplantation Unit, Department of Medical and Surgical 
      Sciences, University of Foggia, Viale Luigi Pinto, 1, 71100, Foggia, Italy.
FAU - Infante, Barbara
AU  - Infante B
AD  - Nephrology, Dialysis and Tranplantation Unit, Department of Medical and Surgical 
      Sciences, University of Foggia, Viale Luigi Pinto, 1, 71100, Foggia, Italy.
FAU - Di Lorenzo, Adelaide
AU  - Di Lorenzo A
AD  - Nephrology, Dialysis and Tranplantation Unit, Department of Medical and Surgical 
      Sciences, University of Foggia, Viale Luigi Pinto, 1, 71100, Foggia, Italy.
FAU - Rascio, Federica
AU  - Rascio F
AD  - Nephrology, Dialysis and Tranplantation Unit, Department of Medical and Surgical 
      Sciences, University of Foggia, Viale Luigi Pinto, 1, 71100, Foggia, Italy.
FAU - Zaza, Gianluigi
AU  - Zaza G
AD  - Renal Unit, Department of Medicine, University-Hospital of Verona, University of 
      Verona, Piazzale A. Stefani 1, 37126, Verona, VR, Italy. gianluigi.zaza@univr.it.
FAU - Grandaliano, Giuseppe
AU  - Grandaliano G
AD  - Nephrology, Dialysis and Tranplantation Unit, Department of Medical and Surgical 
      Sciences, University of Foggia, Viale Luigi Pinto, 1, 71100, Foggia, Italy. 
      giuseppe.grandaliano@unifg.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160531
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/drug effects/*immunology
MH  - Humans
MH  - Models, Biological
MH  - Myeloid-Derived Suppressor Cells/cytology/drug effects
MH  - Protein Kinase Inhibitors/*pharmacology
MH  - T-Lymphocytes, Regulatory/drug effects/*immunology
MH  - TOR Serine-Threonine Kinases/*antagonists & inhibitors/metabolism
PMC - PMC4886438
OTO - NOTNLM
OT  - Dendritic cells
OT  - Operational tolerance
OT  - Transplantation
OT  - Treg
OT  - mTOR inhibitors
EDAT- 2016/06/02 06:00
MHDA- 2017/10/17 06:00
PMCR- 2016/05/31
CRDT- 2016/06/02 06:00
PHST- 2016/02/15 00:00 [received]
PHST- 2016/05/18 00:00 [accepted]
PHST- 2016/06/02 06:00 [entrez]
PHST- 2016/06/02 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
PHST- 2016/05/31 00:00 [pmc-release]
AID - 10.1186/s12967-016-0916-7 [pii]
AID - 916 [pii]
AID - 10.1186/s12967-016-0916-7 [doi]
PST - epublish
SO  - J Transl Med. 2016 May 31;14(1):152. doi: 10.1186/s12967-016-0916-7.