PMID- 27247366
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20170817
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 145
IP  - 5
DP  - 2016 May
TI  - An Immunohistochemical Survey of SNARE Proteins Shows Distinct Patterns of 
      Expression in Hematolymphoid Neoplasia.
PG  - 604-16
LID - 10.1093/ajcp/aqw022 [doi]
AB  - OBJECTIVES: Five proteins from the soluble N-ethylmaleimide-sensitive factor 
      activating protein receptor (SNARE) complex family were studied in normal 
      hematopoietic cells in bone marrow; normal lymphocytes at different stages of 
      maturation and differentiation in bone marrow, thymus, tonsil, and lymph node; 
      malignant lymphomas; and leukemias. METHODS: Sixty-eight reactive and 380 
      hematopoietic and lymphoid neoplasms were immunohistochemically stained for 
      syntaxin 7 (STX7), vesicle-associated membrane proteins (VAMP2, VAMP7, VAMP8), 
      and synaptosomal-associated protein 23 (SNAP23). RESULTS: STX7 has potential for 
      being a useful marker for distinguishing between normal B precursors 
      (hematogones) vs B lymphoblasts, as well as between the "popcorn" cells of 
      nodular lymphocyte-predominant Hodgkin lymphoma vs the Reed-Sternberg cells of 
      classic Hodgkin lymphoma or the B cells of T-cell, histiocyte-rich B-cell 
      lymphoma. VAMP2 is uniquely expressed by both reactive and malignant plasma 
      cells, in contrast to B-cell non-Hodgkin lymphoma. There is differential 
      expression of SNARE proteins in normal and neoplastic lymphoid tissue depending 
      on lymphocyte maturation stage. CONCLUSIONS: Differential SNARE protein 
      expression in the lymphoid system may have potential use in diagnosis and may 
      offer clues to lymphoma biology. VAMP2 is a promising new plasma cell marker.
CI  - (c) American Society for Clinical Pathology, 2016. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Bhat, Rekha
AU  - Bhat R
AD  - From the Department of Pathology, Montefiore Medical Center/Albert Einstein 
      College of Medicine, Bronx, NY rekhabhat@manipalhospitals.com.
FAU - Bhattacharyya, Pritish K
AU  - Bhattacharyya PK
AD  - Department of Pathology, Hackensack University Medical Center, Hackensack, NJ.
FAU - Ratech, Howard
AU  - Ratech H
AD  - From the Department of Pathology, Montefiore Medical Center/Albert Einstein 
      College of Medicine, Bronx, NY.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (SNARE Proteins)
SB  - IM
MH  - Biomarkers, Tumor/*analysis
MH  - Bone Marrow/metabolism
MH  - Hematologic Neoplasms/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphoid Tissue/metabolism
MH  - SNARE Proteins/analysis/*biosynthesis
MH  - Tissue Array Analysis
OTO - NOTNLM
OT  - Leukemia
OT  - Lymphoma
OT  - SNAP23
OT  - SNARE
OT  - Syntaxin7
OT  - VAMP2
OT  - VAMP7
OT  - VAMP8
EDAT- 2016/06/02 06:00
MHDA- 2017/02/24 06:00
CRDT- 2016/06/02 06:00
PHST- 2016/06/02 06:00 [entrez]
PHST- 2016/06/02 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
AID - aqw022 [pii]
AID - 10.1093/ajcp/aqw022 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2016 May;145(5):604-16. doi: 10.1093/ajcp/aqw022.