PMID- 27247608
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160601
LR  - 20220408
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2016
DP  - 2016
TI  - Anti-Inflammatory Effects of Pomegranate Peel Extract in THP-1 Cells Exposed to 
      Particulate Matter PM10.
PG  - 6836080
LID - 10.1155/2016/6836080 [doi]
LID - 6836080
AB  - Epidemiological and experimental evidence support health risks associated with 
      the exposure to airborne particulate matter with a diameter of <10 muM (PM10). 
      PM10 stimulates the production of reactive oxygen species (ROS) and inflammatory 
      mediators. Thus, we assumed that natural antioxidants might provide health 
      benefits attenuating hazardous effects of PM10. In the present study, we examined 
      the effects of pomegranate peel extract (PPE) on THP-1 monocytic cells exposed to 
      PM10. PM10 induced cytotoxicity and the production of ROS. It also increased the 
      expression and secretion of inflammatory cytokines, such as tumor necrosis 
      factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein-1 
      (MCP-1), and cell adhesion molecules, such as intercellular adhesion molecule-1 
      (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). PPE at 10-100 mug mL(-1) 
      attenuated the production of ROS and the expression of TNF-alpha, IL-1beta, MCP-1, and 
      ICAM-1, but not VCAM-1, in THP-1 cells stimulated by PM10 (100 mug mL(-1)). PPE 
      also attenuated the adhesion of PM10-stimulated THP-1 cells to EA.hy926 
      endothelial cells. PPE constituents, punicalagin and ellagic acid, attenuated 
      PM10-induced monocyte adhesion to endothelial cells, and punicalagin was less 
      cytotoxic compared to ellagic acid. The present study suggests that PPE and 
      punicalagin may be useful in alleviating inflammatory reactions due to 
      particulate matter.
FAU - Park, Soojin
AU  - Park S
AD  - Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus 
      KNU Biomedical Convergence Program, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
FAU - Seok, Jin Kyung
AU  - Seok JK
AD  - Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus 
      KNU Biomedical Convergence Program, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
FAU - Kwak, Jun Yup
AU  - Kwak JY
AD  - Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus 
      KNU Biomedical Convergence Program, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea.
FAU - Suh, Hwa-Jin
AU  - Suh HJ
AD  - Gyeongbuk Natural Color Industry Institute, 181 Cheonmun-ro, Yeongcheon-si, 
      Gyeongsangbuk-do 38896, Republic of Korea.
FAU - Kim, Young Mi
AU  - Kim YM
AD  - Ruby Crown Co., Ltd., 201 Kyungpook National University Business Incubation 
      Center, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
FAU - Boo, Yong Chool
AU  - Boo YC
AD  - Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus 
      KNU Biomedical Convergence Program, School of Medicine, Kyungpook National 
      University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea; Ruby 
      Crown Co., Ltd., 201 Kyungpook National University Business Incubation Center, 80 
      Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20160510
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4877489
EDAT- 2016/06/02 06:00
MHDA- 2016/06/02 06:01
PMCR- 2016/05/10
CRDT- 2016/06/02 06:00
PHST- 2016/01/05 00:00 [received]
PHST- 2016/04/14 00:00 [revised]
PHST- 2016/04/18 00:00 [accepted]
PHST- 2016/06/02 06:00 [entrez]
PHST- 2016/06/02 06:00 [pubmed]
PHST- 2016/06/02 06:01 [medline]
PHST- 2016/05/10 00:00 [pmc-release]
AID - 10.1155/2016/6836080 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2016;2016:6836080. doi: 10.1155/2016/6836080. 
      Epub 2016 May 10.