PMID- 27247807
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160601
LR  - 20200929
IS  - 2090-6404 (Print)
IS  - 2090-6412 (Electronic)
IS  - 2090-6404 (Linking)
VI  - 2016
DP  - 2016
TI  - Severe Left Ventricular Hypertrophy, Small Pericardial Effusion, and Diffuse Late 
      Gadolinium Enhancement by Cardiac Magnetic Resonance Suspecting Cardiac 
      Amyloidosis: Endomyocardial Biopsy Reveals an Unexpected Diagnosis.
PG  - 2461502
LID - 10.1155/2016/2461502 [doi]
LID - 2461502
AB  - Left ventricular (LV) hypertrophy can be related to a multitude of cardiac 
      disorders, such as hypertrophic cardiomyopathy (HCM), cardiac amyloidosis, and 
      hypertensive heart disease. Although the presence of LV hypertrophy is generally 
      associated with poorer cardiac outcomes, the early differentiation between these 
      pathologies is crucial due to the presence of specific treatment options. The 
      diagnostic process with LV hypertrophy requires the integration of clinical 
      evaluation, electrocardiography (ECG), echocardiography, biochemical markers, and 
      if required CMR and endomyocardial biopsy in order to reach the correct 
      diagnosis. Here, we present a case of a patient with severe LV hypertrophy 
      (septal wall thickness of 23 mm, LV mass of 264 g, and LV mass index of 
      147 g/m(2)), severely impaired longitudinal function, and preserved radial 
      contractility (ejection fraction = 55%), accompanied by small pericardial 
      effusion and diffuse late gadolinium enhancement (LGE) by cardiac magnetic 
      resonance (CMR). Due to the imaging findings, an infiltrative cardiomyopathy, 
      such as cardiac amyloidosis, was suspected. However, amyloid accumulation was 
      excluded by endomyocardial biopsy, which revealed the presence of diffuse 
      myocardial fibrosis in an advanced hypertensive heart disease.
FAU - Hofmann, Nina P
AU  - Hofmann NP
AD  - Department of Cardiology & Vascular Medicine, GRN Hospital Weinheim, 69469 
      Weinheim, Germany.
FAU - Giusca, Sorin
AU  - Giusca S
AD  - Department of Cardiology & Vascular Medicine, GRN Hospital Weinheim, 69469 
      Weinheim, Germany.
FAU - Klingel, Karin
AU  - Klingel K
AD  - Department of Molecular Pathology, University Hospital Tubingen, Tubingen, 
      Germany.
FAU - Nunninger, Peter
AU  - Nunninger P
AD  - Department of Radiology, GRN Hospital Weinheim, 69469 Weinheim, Germany.
FAU - Korosoglou, Grigorios
AU  - Korosoglou G
AD  - Department of Cardiology & Vascular Medicine, GRN Hospital Weinheim, 69469 
      Weinheim, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160510
PL  - United States
TA  - Case Rep Cardiol
JT  - Case reports in cardiology
JID - 101576452
PMC - PMC4877463
EDAT- 2016/06/02 06:00
MHDA- 2016/06/02 06:01
PMCR- 2016/05/10
CRDT- 2016/06/02 06:00
PHST- 2016/01/31 00:00 [received]
PHST- 2016/04/16 00:00 [revised]
PHST- 2016/04/24 00:00 [accepted]
PHST- 2016/06/02 06:00 [entrez]
PHST- 2016/06/02 06:00 [pubmed]
PHST- 2016/06/02 06:01 [medline]
PHST- 2016/05/10 00:00 [pmc-release]
AID - 10.1155/2016/2461502 [doi]
PST - ppublish
SO  - Case Rep Cardiol. 2016;2016:2461502. doi: 10.1155/2016/2461502. Epub 2016 May 10.