PMID- 27247948
OWN - NLM
STAT- MEDLINE
DCOM- 20170627
LR  - 20240325
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes.
PG  - 4626382
LID - 10.1155/2016/4626382 [doi]
LID - 4626382
AB  - Aims. We aimed to investigate the sex differences in the renal function decline 
      among patients with type 2 diabetic mellitus (T2DM), focusing on the differences 
      in the risk factors at early stage of renal dysfunction. Methods. A clinic-based 
      retrospective longitudinal study (follow-up duration: 8.1 +/- 1.4 years) was 
      conducted to assess the sex differences in the annual estimated glomerular 
      filtration rate (eGFR) change in 344 (247 male and 97 female) Japanese T2DM 
      patients. The sex differences in the risk factors of annual eGFR decline were 
      subjected to linear regression analyses. Results. The mean annual eGFR change was 
      -3.5 +/- 2.7%/year in females and -2.0 +/- 2.2%/year in males (P < 0.001). Baseline 
      retinopathy and proteinuria were significantly associated with a larger eGFR 
      decline, irrespective of sex, while HbA1c and LDL-cholesterol levels were 
      significantly associated with an eGFR decline in females only. Interactive 
      effects were observed between sex and the HbA1c, LDL-cholesterol, retinopathy, or 
      proteinuria levels on the annual eGFR decline. Conclusions. The increased 
      susceptibility to poor metabolic control seemed to contribute to a higher risk of 
      renal dysfunction in females with T2DM. Our study highlights the importance of 
      aggressive therapeutic intervention to improve metabolic profiles at early stage, 
      especially in females.
FAU - Kajiwara, Ayami
AU  - Kajiwara A
AD  - Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical 
      Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, 
      Japan.
FAU - Kita, Ayana
AU  - Kita A
AD  - Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical 
      Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, 
      Japan.
FAU - Saruwatari, Junji
AU  - Saruwatari J
AD  - Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical 
      Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, 
      Japan; Center for Clinical Pharmaceutical Sciences, Kumamoto University, 5-1 
      Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
FAU - Miyazaki, Hiroko
AU  - Miyazaki H
AD  - Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical 
      Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, 
      Japan.
FAU - Kawata, Yuki
AU  - Kawata Y
AD  - Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical 
      Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, 
      Japan.
FAU - Morita, Kazunori
AU  - Morita K
AD  - Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical 
      Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, 
      Japan.
FAU - Oniki, Kentaro
AU  - Oniki K
AD  - Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical 
      Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, 
      Japan.
FAU - Yoshida, Akira
AU  - Yoshida A
AD  - Jinnouchi Clinic, Diabetes Care Center, 6-2-3 Kuhonji, Chuo-ku, Kumamoto 
      862-0976, Japan.
FAU - Jinnouchi, Hideaki
AU  - Jinnouchi H
AD  - Jinnouchi Clinic, Diabetes Care Center, 6-2-3 Kuhonji, Chuo-ku, Kumamoto 
      862-0976, Japan.
FAU - Nakagawa, Kazuko
AU  - Nakagawa K
AD  - Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical 
      Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, 
      Japan; Center for Clinical Pharmaceutical Sciences, Kumamoto University, 5-1 
      Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
LA  - eng
PT  - Journal Article
DEP - 20160509
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cholesterol, LDL/metabolism
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Diabetic Nephropathies/epidemiology/etiology/*physiopathology
MH  - Diabetic Retinopathy/epidemiology
MH  - Female
MH  - *Glomerular Filtration Rate
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Japan/epidemiology
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Proteinuria/epidemiology
MH  - Renal Insufficiency/epidemiology/etiology/*physiopathology
MH  - Retrospective Studies
MH  - Sex Factors
PMC - PMC4876234
EDAT- 2016/06/02 06:00
MHDA- 2017/06/28 06:00
PMCR- 2016/05/09
CRDT- 2016/06/02 06:00
PHST- 2016/01/23 00:00 [received]
PHST- 2016/04/03 00:00 [revised]
PHST- 2016/04/13 00:00 [accepted]
PHST- 2016/06/02 06:00 [entrez]
PHST- 2016/06/02 06:00 [pubmed]
PHST- 2017/06/28 06:00 [medline]
PHST- 2016/05/09 00:00 [pmc-release]
AID - 10.1155/2016/4626382 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:4626382. doi: 10.1155/2016/4626382. Epub 2016 May 9.