PMID- 27248312
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20170428
IS  - 1549-7801 (Electronic)
IS  - 0738-8551 (Linking)
VI  - 37
IP  - 4
DP  - 2017 Jun
TI  - Chitosan magnetic nanoparticles for drug delivery systems.
PG  - 492-509
LID - 10.1080/07388551.2016.1185389 [doi]
AB  - The potential of magnetic nanoparticles (MNPs) in drug delivery systems (DDSs) is 
      mainly related to its magnetic core and surface coating. These coatings can 
      eliminate or minimize their aggregation under physiological conditions. Also, 
      they can provide functional groups for bioconjugation to anticancer drugs and/or 
      targeted ligands. Chitosan, as a derivative of chitin, is an attractive natural 
      biopolymer from renewable resources with the presence of reactive amino and 
      hydroxyl functional groups in its structure. Chitosan nanoparticles (NPs), due to 
      their huge surface to volume ratio as compared to the chitosan in its bulk form, 
      have outstanding physico-chemical, antimicrobial and biological properties. These 
      unique properties make chitosan NPs a promising biopolymer for the application of 
      DDSs. In this review, the current state and challenges for the application 
      magnetic chitosan NPs in drug delivery systems were investigated. The present 
      review also revisits the limitations and commercial impediments to provide 
      insight for future works.
FAU - Assa, Farnaz
AU  - Assa F
AD  - a Faculty of Chemical Engineering , Sahand University of Technology , Tabriz , 
      Iran.
FAU - Jafarizadeh-Malmiri, Hoda
AU  - Jafarizadeh-Malmiri H
AD  - a Faculty of Chemical Engineering , Sahand University of Technology , Tabriz , 
      Iran.
FAU - Ajamein, Hossein
AU  - Ajamein H
AD  - b Department of Chemical Engineering , Ilkhchi Branch, Islamic Azad University , 
      Ilkhchi , Iran.
FAU - Vaghari, Hamideh
AU  - Vaghari H
AD  - a Faculty of Chemical Engineering , Sahand University of Technology , Tabriz , 
      Iran.
FAU - Anarjan, Navideh
AU  - Anarjan N
AD  - c Department of Chemical Engineering , Tabriz Branch, Islamic Azad University , 
      Tabriz , Iran.
FAU - Ahmadi, Omid
AU  - Ahmadi O
AD  - a Faculty of Chemical Engineering , Sahand University of Technology , Tabriz , 
      Iran.
FAU - Berenjian, Aydin
AU  - Berenjian A
AD  - d Faculty of Science and Engineering, School of Engineering , University of 
      Waikato , Hamilton , New Zealand.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160601
PL  - England
TA  - Crit Rev Biotechnol
JT  - Critical reviews in biotechnology
JID - 8505177
RN  - 0 (Biopolymers)
RN  - 0 (Magnetite Nanoparticles)
RN  - 1398-61-4 (Chitin)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Biopolymers/*chemistry/therapeutic use
MH  - Chitin/chemistry
MH  - Chitosan/*chemistry/therapeutic use
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Magnetite Nanoparticles/*chemistry/therapeutic use
OTO - NOTNLM
OT  - Biocompatible
OT  - biodegradable
OT  - biomedical
OT  - carrier
OT  - chitosan
OT  - drug delivery system
OT  - magnetic nanoparticles
OT  - toxicity
EDAT- 2016/06/02 06:00
MHDA- 2017/04/30 06:00
CRDT- 2016/06/02 06:00
PHST- 2016/06/02 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
PHST- 2016/06/02 06:00 [entrez]
AID - 10.1080/07388551.2016.1185389 [doi]
PST - ppublish
SO  - Crit Rev Biotechnol. 2017 Jun;37(4):492-509. doi: 10.1080/07388551.2016.1185389. 
      Epub 2016 Jun 1.