PMID- 27249415
OWN - NLM
STAT- MEDLINE
DCOM- 20180822
LR  - 20180822
IS  - 1752-699X (Electronic)
IS  - 1752-6981 (Linking)
VI  - 12
IP  - 1
DP  - 2018 Jan
TI  - Association between fractional exhaled nitric oxide (FeNO) cutoff values (25 ppb) 
      and risk factors of cough.
PG  - 193-199
LID - 10.1111/crj.12512 [doi]
AB  - INTRODUCTION: Cough is among the most common symptoms for patients to seek 
      medical attention. OBJECTIVES: The purpose of this study is to evaluate the 
      association between fractional exhaled nitric oxide (FeNO) cutoff values (25 ppb) 
      and risk factors related to cough, hoping to evaluate the feasibility of the FeNO 
      cut point values (25 ppb) for clinical prediction of cough in etiology. METHODS: 
      In 107 adult patients with acute, subacute, or chronic cough, the FeNO, forced 
      expiratory volume for 1 second (FEV1), forced vital capacity (FVC), blood routine 
      (white blood cell and neutrophil), immunoglobulin E (IgE), lymphocyte 
      eosinophils, and hemoglobin were measured. The Student's t-test was used to test 
      the differences of FeNO levels compared with FEV1/FVC, lymphocyte, and hemoglobin 
      level. For evaluating the correlation of FeNO levels with IgE, eosinophil, blood 
      routine, pulmonary infection, and smoking status, the chi-square test was 
      performed. RESULTS: FeNO cutoff value (25 ppb) significantly correlated with 
      serum IgE (P < .0001) between >/=200 IU/mL and <200 IU/mL level, eosinophil 
      (P = .039) between >/=5% and <5% level, lymphocyte percentage (P = .032) and the 
      ratio of FEV1/FVC (P = .032), while weakly correlated with pulmonary infection, 
      blood routine (white blood cell and neutrophil), hemoglobin, and smoking. 
      CONCLUSION: The cutoff values of FeNO (>/=25 ppb or <25 ppb) are useful for 
      etiological detection of cough with high sensitivity.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Qian, Ling
AU  - Qian L
AD  - Department of Respiratory Medicine, The Fifth People's Hospital of Shanghai, 
      Fudan University, Shanghai, 200240, China.
FAU - Pan, Shiying
AU  - Pan S
AD  - Department of Respiratory Medicine, The Fifth People's Hospital of Shanghai, 
      Fudan University, Shanghai, 200240, China.
FAU - Shi, Jingdong
AU  - Shi J
AD  - Department of Respiratory Medicine, The Fifth People's Hospital of Shanghai, 
      Fudan University, Shanghai, 200240, China.
FAU - Du, Yong
AU  - Du Y
AD  - Department of Respiratory Medicine, The Fifth People's Hospital of Shanghai, 
      Fudan University, Shanghai, 200240, China.
FAU - Huang, Qihui
AU  - Huang Q
AD  - Department of Respiratory Medicine, The Fifth People's Hospital of Shanghai, 
      Fudan University, Shanghai, 200240, China.
FAU - Jie, Zhijun
AU  - Jie Z
AD  - Department of Respiratory Medicine, The Fifth People's Hospital of Shanghai, 
      Fudan University, Shanghai, 200240, China.
LA  - eng
PT  - Journal Article
DEP - 20160622
PL  - England
TA  - Clin Respir J
JT  - The clinical respiratory journal
JID - 101315570
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breath Tests
MH  - Chronic Disease
MH  - Cough/diagnosis/*etiology/physiopathology
MH  - Exhalation/*physiology
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*analysis
MH  - Respiratory Function Tests
MH  - Risk Factors
MH  - Vital Capacity
MH  - Young Adult
OTO - NOTNLM
OT  - clinical diagnose
OT  - cough
OT  - cutoff values
OT  - fractional exhaled nitric oxide
EDAT- 2016/06/02 06:00
MHDA- 2018/08/23 06:00
CRDT- 2016/06/02 06:00
PHST- 2015/07/28 00:00 [received]
PHST- 2016/03/31 00:00 [revised]
PHST- 2016/05/29 00:00 [accepted]
PHST- 2016/06/02 06:00 [pubmed]
PHST- 2018/08/23 06:00 [medline]
PHST- 2016/06/02 06:00 [entrez]
AID - 10.1111/crj.12512 [doi]
PST - ppublish
SO  - Clin Respir J. 2018 Jan;12(1):193-199. doi: 10.1111/crj.12512. Epub 2016 Jun 22.