PMID- 27250889
OWN - NLM
STAT- MEDLINE
DCOM- 20180920
LR  - 20181004
IS  - 2078-2101 (Print)
IS  - 2078-2101 (Linking)
VI  - 1
IP  - 21
DP  - 2016 May
TI  - Efficacy of Different Protocols in Treatment of Nephroblastoma: A revisit.
PG  - 55-60
AB  - BACKGROUND: Management of Nephroblastoma (NB) remains a subject of debate despite 
      the fact that it ranked first among primary childhood's renal neoplasm. We have 
      previously discussed this issue 13, 14, yet, the sample size was limited. AIM: 
      The aim of this study was to further evaluate the efficacy of initial surgery in 
      the treatment of stage II and III pediatric NB as a part of the short 
      administration schedule as in National Wilms' Tumor Study (NWTS)-4 and to 
      evaluate its effectiveness compared to the long administration schedule. PATIENTS 
      AND METHODS: The study included 50 children who were primarily diagnosed as stage 
      II and III NB. They were divided into 2 equal groups. Group I (n = 25) included 
      children who have undergone neoadjuvant chemotherapy followed by surgery and 
      postoperative chemotherapy, while group II (n = 25) included children who have 
      undergone primary surgery as an initial management followed by chemotherapy. 
      After a mean postoperative follow-up period of 20+/-6 months, clinical and 
      radiological evaluation was performed to all patients. RESULTS: In group I, 15 
      patients were preoperatively diagnosed as stage II and 10 patients as stage III 
      while in group II, 16 patients were proved to be stage II and 9 patients were 
      stage III. After a follow up period, clinical and radiological evaluation using 
      CT was performed to all patients. In patients with stage II, evidence of 
      recurrence was noted in 5 patients of group I whereas no patient showed any 
      evidence of recurrence in group II. In patients with stage III, rebound increase 
      in size was seen in 3 patients in group I and only one patient in group II. 
      CONCLUSIONS: This study confirmed our previous conclusions that initial surgical 
      intervention with appropriate adjuvant therapy has a better outcome than the 
      neoadjuvant chemotherapy and delayed surgery for children primarily diagnosed as 
      stage II and III NB. Moreover, it may also act as a short administration schedule 
      for the treatment as it is not less effective than the long administration 
      schedule and can be administered at a substantially lower total treatment cost.
FAU - Zakaria, O M
AU  - Zakaria OM
AD  - Department of Surgery, College of Medicine, King Faisal University, Al Ahsa, KSA.
AD  - Department of Surgery, Faculty of Medicine, Suez Canal University, Egypt.
FAU - Daoud, M Y I
AU  - Daoud MY
AD  - Department of Surgery, College of Medicine, King Faisal University, Al Ahsa, KSA.
FAU - Farrag, S H
AU  - Farrag SH
AD  - Department of Surgery, Faculty of Medicine, Suez Canal University, Egypt.
FAU - Mulhim, A S
AU  - Mulhim AS
AD  - Department of Surgery, College of Medicine, King Faisal University, Al Ahsa, KSA.
LA  - eng
PT  - Journal Article
PL  - Kuwait
TA  - Gulf J Oncolog
JT  - The Gulf journal of oncology
JID - 101500911
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Child
MH  - Humans
MH  - Infant
MH  - Kidney Neoplasms/*therapy
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Treatment Outcome
MH  - Wilms Tumor/*therapy
OTO - NOTNLM
OT  - Chemotherapy and Surgery.
OT  - Children
OT  - NWTSG4
OT  - Nephroblastoma
OT  - SIOP
EDAT- 2016/06/03 06:00
MHDA- 2018/09/21 06:00
CRDT- 2016/06/03 06:00
PHST- 2016/04/15 00:00 [accepted]
PHST- 2016/06/03 06:00 [entrez]
PHST- 2016/06/03 06:00 [pubmed]
PHST- 2018/09/21 06:00 [medline]
PST - ppublish
SO  - Gulf J Oncolog. 2016 May;1(21):55-60.