PMID- 27252876
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160602
LR  - 20210112
IS  - 2053-3624 (Print)
IS  - 2053-3624 (Electronic)
IS  - 2053-3624 (Linking)
VI  - 3
IP  - 1
DP  - 2016
TI  - Observed change in peak oxygen consumption after aortic valve replacement and its 
      predictors.
PG  - e000309
LID - 10.1136/openhrt-2015-000309 [doi]
LID - e000309
AB  - OBJECTIVE: To assess the change in peak oxygen consumption (pVO2) and determine 
      its outcome predictors after aortic valve replacement (AVR) for aortic stenosis 
      (AS). METHODS: Patients with AS and preserved left ventricular ejection fraction 
      who were referred for single AVR had cardiopulmonary exercise testing prior to 
      and 9 months post-AVR. Predictors of outcome for pVO2 were determined by 
      multivariate linear and logistic regression analyses. A significant change in 
      pVO2 was defined as a relative change that was more than twice the coefficient of 
      repeatability by test-retest (>10%). RESULTS: The pre-AVR characteristics of the 
      37 study patients included the following: median age (range) 72 (46-83) years, 
      aortic valve area index (AVAI) 0.41 (SD 0.11) cm(2)/m(2), mean gradient (MG) 49.1 
      (SD 15.3) mm Hg and New York Heart Association (NYHA)>/=II 27 (73%). Pre-AVR and 
      post-AVR mean pVO2 was 18.5 and 18.4 mL/kg/m(2) (87% of the predicted), 
      respectively, but the change from pre-AVR was heterogeneous. The relative change 
      in pVO2 was positively associated with the preoperative MG (beta=0.50, p=0.001) and 
      negatively associated with brain natriuretic peptide > upper level of normal 
      according to age and gender (beta=-0.40, p=0.009). A relative increase in pVO2 
      exceeding 10% was found in 9 (24%), predicted by lower pre-AVR AVAI (OR 0.18; 95% 
      CI 0.04 to 0.82, p=0.027) and lower peak O2 pulse (OR 0.94; 95% CI 0.88 to 0.99, 
      p=0.045). Decreases in pVO2 exceeding 10% were found in 11 (30%) and predicted by 
      lower MG (OR 0.93; 95% CI 0.86 to 0.99, p=0.033). CONCLUSIONS: Change in pVO2 was 
      heterogeneous. Predictors of favourable and unfavourable outcomes for pVO2 were 
      identified.
FAU - Le, Van Doan Tuyet
AU  - Le VD
AD  - Department of Cardiology , Roskilde University Hospital , Roskilde , Denmark.
FAU - Jensen, Gunnar Vagn Hagemann
AU  - Jensen GV
AD  - Department of Cardiology , Roskilde University Hospital , Roskilde , Denmark.
FAU - Kjoller-Hansen, Lars
AU  - Kjoller-Hansen L
AD  - Department of Cardiology , Roskilde University Hospital , Roskilde , Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160526
PL  - England
TA  - Open Heart
JT  - Open heart
JID - 101631219
PMC - PMC4885434
EDAT- 2016/06/03 06:00
MHDA- 2016/06/03 06:01
PMCR- 2016/05/26
CRDT- 2016/06/03 06:00
PHST- 2015/06/26 00:00 [received]
PHST- 2016/03/18 00:00 [revised]
PHST- 2016/04/25 00:00 [accepted]
PHST- 2016/06/03 06:00 [entrez]
PHST- 2016/06/03 06:00 [pubmed]
PHST- 2016/06/03 06:01 [medline]
PHST- 2016/05/26 00:00 [pmc-release]
AID - openhrt-2015-000309 [pii]
AID - 10.1136/openhrt-2015-000309 [doi]
PST - epublish
SO  - Open Heart. 2016 May 26;3(1):e000309. doi: 10.1136/openhrt-2015-000309. 
      eCollection 2016.