PMID- 27256017
OWN - NLM
STAT- MEDLINE
DCOM- 20170525
LR  - 20220310
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 212
DP  - 2016 Jun
TI  - Porcine respiratory disease complex: Interaction of vaccination and porcine 
      circovirus type 2, porcine reproductive and respiratory syndrome virus, and 
      Mycoplasma hyopneumoniae.
PG  - 1-6
LID - S1090-0233(15)00439-6 [pii]
LID - 10.1016/j.tvjl.2015.10.030 [doi]
AB  - Porcine respiratory disease is a multifactorial and complex disease caused by a 
      combination of infectious pathogens, environmental stressors, differences in 
      production systems, and various management practices; hence the name porcine 
      respiratory disease complex (PRDC) is used. Porcine circovirus type 2 (PCV2), 
      porcine reproductive and respiratory syndrome virus (PRRSV), and Mycoplasma 
      hyopneumoniae are considered to be the most important pathogens that cause PRDC. 
      Although interactions among the three major respiratory pathogens are well 
      documented, it is also necessary to understand the interaction between vaccines 
      and the three major respiratory pathogens. PRRSV and M. hyopneumoniae are well 
      known to potentiate PCV2-associated lesions; however, PRRSV and mycoplasmal 
      vaccines can both enhance PCV2 viraemia regardless of the effects of the actual 
      PRRSV or M. hyopneumoniae infection. On the other hand, M. hyopneumoniae 
      potentiates the severity of pneumonia induced by PRRSV, and vaccination against 
      M. hyopneumoniae alone is also able to decrease PRRSV viraemia and PRRSV-induced 
      lung lesions in dually infected pigs. This review focuses on (1) interactions 
      between PCV2, PRRSV, and M. hyopneumoniae; and (2) interactions between vaccines 
      and the three major respiratory pathogens.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea. 
      Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151023
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
SB  - IM
MH  - Animals
MH  - Circoviridae Infections/epidemiology/*prevention & control/virology
MH  - Circovirus/physiology
MH  - Incidence
MH  - Mycoplasma hyopneumoniae/physiology
MH  - Pneumonia of Swine, Mycoplasmal/epidemiology/*prevention & control/virology
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/*prevention & 
      control/virology
MH  - Porcine respiratory and reproductive syndrome virus/physiology
MH  - Swine
MH  - Vaccination/*veterinary
OTO - NOTNLM
OT  - Mycoplasma hyopneumoniae
OT  - Porcine circovirus type 2
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Porcine respiratory disease complex
OT  - Vaccine
EDAT- 2016/06/04 06:00
MHDA- 2017/05/26 06:00
CRDT- 2016/06/04 06:00
PHST- 2015/01/03 00:00 [received]
PHST- 2015/07/27 00:00 [revised]
PHST- 2015/10/10 00:00 [accepted]
PHST- 2016/06/04 06:00 [entrez]
PHST- 2016/06/04 06:00 [pubmed]
PHST- 2017/05/26 06:00 [medline]
AID - S1090-0233(15)00439-6 [pii]
AID - 10.1016/j.tvjl.2015.10.030 [doi]
PST - ppublish
SO  - Vet J. 2016 Jun;212:1-6. doi: 10.1016/j.tvjl.2015.10.030. Epub 2015 Oct 23.