PMID- 27256370
OWN - NLM
STAT- MEDLINE
DCOM- 20171026
LR  - 20181113
IS  - 1863-2300 (Electronic)
IS  - 1863-2297 (Print)
IS  - 1863-2297 (Linking)
VI  - 38
IP  - 4
DP  - 2016 Jul
TI  - Dendritic cells in lung immunopathology.
PG  - 449-60
LID - 10.1007/s00281-016-0571-3 [doi]
AB  - Dendritic cells (DCs) lie at the heart of the innate immune system, specialised 
      at recognising danger signals in many forms including foreign material, infection 
      or tissue damage and initiating powerful adaptive immune and inflammatory 
      responses. In barrier sites such as the lung, the instrumental role that DCs play 
      at the interface between the environment and the host places them in a pivotal 
      position in determining the severity of inflammatory disease. The past few years 
      has seen a significant increase in our fundamental understanding of the subsets 
      of DCs involved in pulmonary immunity, as well as the mechanisms by which they 
      are activated and which they may use to coordinate downstream inflammation and 
      pathology. In this review, we will summarise current understanding of the 
      multi-faceted role that DCs play in the induction, maintenance and regulation of 
      lung immunopathology, with an emphasis on allergic pulmonary disease.
FAU - Cook, Peter C
AU  - Cook PC
AD  - Manchester Collaborative Centre for Inflammation Research, Core Technology 
      Facility, The University of Manchester, 46 Grafton Street, M13 9NT, Manchester, 
      UK.
FAU - MacDonald, Andrew S
AU  - MacDonald AS
AD  - Manchester Collaborative Centre for Inflammation Research, Core Technology 
      Facility, The University of Manchester, 46 Grafton Street, M13 9NT, Manchester, 
      UK. andrew.macdonald@manchester.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160602
PL  - Germany
TA  - Semin Immunopathol
JT  - Seminars in immunopathology
JID - 101308769
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Cell Communication
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Hypersensitivity/epidemiology/immunology/metabolism
MH  - Immune Tolerance/immunology
MH  - Immunity, Innate
MH  - Inflammation Mediators/metabolism
MH  - Lung/*immunology/metabolism/pathology
MH  - Lung Diseases/epidemiology/*etiology/metabolism/pathology
MH  - Lymphocyte Activation/immunology
MH  - Respiratory Mucosa/immunology/metabolism
MH  - T-Lymphocyte Subsets/immunology/metabolism
PMC - PMC4896986
OTO - NOTNLM
OT  - Allergies
OT  - Asthma
OT  - Dendritic cells
OT  - Lung
OT  - Th17
OT  - Th2
COIS- Compliance with ethical standards Disclosure The MCCIR is a joint venture between 
      the University of Manchester, AstraZeneka and GSK.
EDAT- 2016/06/04 06:00
MHDA- 2017/10/27 06:00
PMCR- 2016/06/02
CRDT- 2016/06/04 06:00
PHST- 2016/05/06 00:00 [received]
PHST- 2016/05/09 00:00 [accepted]
PHST- 2016/06/04 06:00 [entrez]
PHST- 2016/06/04 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
PHST- 2016/06/02 00:00 [pmc-release]
AID - 10.1007/s00281-016-0571-3 [pii]
AID - 571 [pii]
AID - 10.1007/s00281-016-0571-3 [doi]
PST - ppublish
SO  - Semin Immunopathol. 2016 Jul;38(4):449-60. doi: 10.1007/s00281-016-0571-3. Epub 
      2016 Jun 2.