PMID- 27258667
OWN - NLM
STAT- MEDLINE
DCOM- 20180115
LR  - 20180115
IS  - 1521-3765 (Electronic)
IS  - 0947-6539 (Linking)
VI  - 22
IP  - 27
DP  - 2016 Jun 27
TI  - An Easy Access to Organic Salt-Based Stimuli-Responsive and Multifunctional 
      Supramolecular Hydrogels.
PG  - 9267-76
LID - 10.1002/chem.201601136 [doi]
AB  - By exploiting orthogonal hydrogen bonding involving supramolecular synthons and 
      hydrophobic/hydrophilic interactions, a new series of simple organic salt based 
      hydrogelators derived from pyrene butyric acid and its beta-alanine amide 
      derivative, and various primary amines has been achieved. The hydrogels were 
      characterised by microscopy, table-top rheology and dynamic rheology. FTIR, 
      variable-temperature (1) H NMR and emission spectroscopy established the role of 
      various supramolecular interactions such as hydrogen bonding and pi-pi stacking in 
      hydrogelation. Single-crystal X-ray diffraction (SXRD) studies supported the 
      conclusion that orthogonal hydrogen bonding involving amide-amide and primary 
      ammonium monocarboxylate (PAM) synthons indeed played a crucial role in 
      hydrogelation. The hydrogels were found to be stimuli-responsive and were capable 
      of sensing ammonia and adsorbing water-soluble dye (methylene blue). All the 
      hydrogelators were biocompatible (MTT assay in RAW 264.7 cells), indicating their 
      suitability for use in drug delivery.
CI  - (c) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Majumder, Joydeb
AU  - Majumder J
AD  - Department of Organic Chemistry, Indian Association for the Cultivation of 
      Science, 2A & 2B Raja S. C. Mullick Road, Kolkata, 700032, India.
FAU - Dastidar, Parthasarathi
AU  - Dastidar P
AUID- ORCID: 0000-0002-1011-2386
AD  - Department of Organic Chemistry, Indian Association for the Cultivation of 
      Science, 2A & 2B Raja S. C. Mullick Road, Kolkata, 700032, India. 
      ocpd@iacs.res.in.
LA  - eng
PT  - Journal Article
DEP - 20160603
PL  - Germany
TA  - Chemistry
JT  - Chemistry (Weinheim an der Bergstrasse, Germany)
JID - 9513783
RN  - 0 (Biocompatible Materials)
RN  - 0 (Drug Carriers)
RN  - 0 (Hydrogels)
RN  - 0 (Pyrenes)
RN  - 11P2JDE17B (beta-Alanine)
RN  - 3443-45-6 (1-pyrenebutyrate)
RN  - 4726-85-6 (beta-alanine amide)
RN  - 7664-41-7 (Ammonia)
RN  - T42P99266K (Methylene Blue)
SB  - IM
MH  - Adsorption
MH  - Ammonia/analysis
MH  - Animals
MH  - Biocompatible Materials/chemical synthesis/chemistry/toxicity
MH  - Cell Survival/drug effects
MH  - Crystallography, X-Ray
MH  - Drug Carriers/chemistry
MH  - Hydrogels/chemical synthesis/*chemistry/toxicity
MH  - Hydrogen Bonding
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Magnetic Resonance Spectroscopy
MH  - Methylene Blue/chemistry
MH  - Mice
MH  - Pyrenes/*chemistry
MH  - RAW 264.7 Cells
MH  - Rheology
MH  - Spectroscopy, Fourier Transform Infrared
MH  - beta-Alanine/analogs & derivatives/chemistry
OTO - NOTNLM
OT  - dye adsorption
OT  - gels
OT  - self-assembly
OT  - sensors
OT  - supramolecular chemistry
EDAT- 2016/06/04 06:00
MHDA- 2018/01/16 06:00
CRDT- 2016/06/04 06:00
PHST- 2016/03/10 00:00 [received]
PHST- 2016/06/04 06:00 [entrez]
PHST- 2016/06/04 06:00 [pubmed]
PHST- 2018/01/16 06:00 [medline]
AID - 10.1002/chem.201601136 [doi]
PST - ppublish
SO  - Chemistry. 2016 Jun 27;22(27):9267-76. doi: 10.1002/chem.201601136. Epub 2016 Jun 
      3.