PMID- 27258734
OWN - NLM
STAT- MEDLINE
DCOM- 20170717
LR  - 20180214
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 47
DP  - 2016 Aug
TI  - Cell adhesion induces overexpression of chromodomain helicase/ATPase DNA binding 
      protein 1-like gene (CHD1L) and contributes to cell adhesion-mediated drug 
      resistance (CAM-DR) in multiple myeloma cells.
PG  - 54-62
LID - S0145-2126(16)30107-2 [pii]
LID - 10.1016/j.leukres.2016.05.007 [doi]
AB  - Previous studies have shown that chromodomain helicase/ATPase DNA binding protein 
      1-like gene (CHD1L) exerts its anti-apoptotic function in many solid cancers. 
      However, its role in human multiple myeloma (MM) has not been thoroughly 
      elucidated. In this study, we investigate the role of CHD1L in MM. Preliminarily, 
      up-regulation and down-regulation assay verified that CHD1L exerts its 
      anti-apoptotic role through the apoptotic pathway involving caspase-9-caspase-3 
      apoptotic pathway in MM cells. In addition, we determined that CHD1L expression 
      is increased when MM cells were adhered to fibronectin (FN) or bone marrow 
      stromal cell line HS-5 cells and cell adhesion assay indicated that CHD1L siRNA 
      reversed the high cell adhesion rate. Consistent with the reduced adhesion rate, 
      the cells translated to a compromised cell adhesion-mediated drug resistance 
      (CAM-DR) phenotype in MM. In summary, we will propose strategies for developing a 
      CHD1L inhibitor for potential treatment of MM.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Xu, Xiaohong
AU  - Xu X
AD  - Affiliated Cancer Hospital of Nantong University, Nantong, 226001 Jiangsu, 
      People's Republic of China.
FAU - He, Yunhua
AU  - He Y
AD  - Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, 
      Medical College, Nantong University, Nantong, 226001 Jiangsu, People's Republic 
      of China.
FAU - Miao, Xiaobing
AU  - Miao X
AD  - Department of Pathology, Affiliated Cancer Hospital of Nantong University, 
      Nantong, 226001 Jiangsu, People's Republic of China.
FAU - Wu, Yaxun
AU  - Wu Y
AD  - Department of Pathology, Affiliated Cancer Hospital of Nantong University, 
      Nantong, 226001 Jiangsu, People's Republic of China.
FAU - Han, Jingling
AU  - Han J
AD  - Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, 
      Medical College, Nantong University, Nantong, 226001 Jiangsu, People's Republic 
      of China.
FAU - Wang, Qiru
AU  - Wang Q
AD  - Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, 
      Medical College, Nantong University, Nantong, 226001 Jiangsu, People's Republic 
      of China.
FAU - Liu, Jing
AU  - Liu J
AD  - Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, 
      Medical College, Nantong University, Nantong, 226001 Jiangsu, People's Republic 
      of China.
FAU - Zhong, Fei
AU  - Zhong F
AD  - Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, 
      Medical College, Nantong University, Nantong, 226001 Jiangsu, People's Republic 
      of China.
FAU - Ou, Yangyu
AU  - Ou Y
AD  - Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, 
      Medical College, Nantong University, Nantong, 226001 Jiangsu, People's Republic 
      of China.
FAU - Wang, Yuchan
AU  - Wang Y
AD  - Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, 
      Medical College, Nantong University, Nantong, 226001 Jiangsu, People's Republic 
      of China. Electronic address: wangyuchan@ntu.edu.cn.
FAU - He, Song
AU  - He S
AD  - Department of Pathology, Affiliated Cancer Hospital of Nantong University, 
      Nantong, 226001 Jiangsu, People's Republic of China. Electronic address: 
      hesong2009@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160512
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (RNA, Small Interfering)
RN  - EC 3.6.4.- (DNA Helicases)
RN  - EC 3.6.4.12 (CHD1 protein, human)
SB  - IM
MH  - Apoptosis Regulatory Proteins/metabolism
MH  - Bone Marrow Cells
MH  - Cell Adhesion/drug effects/*physiology
MH  - Cell Line, Tumor
MH  - DNA Helicases/*genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Drug Resistance, Neoplasm/*genetics
MH  - Humans
MH  - Multiple Myeloma/*pathology
MH  - RNA, Small Interfering/pharmacology
MH  - Stromal Cells
MH  - Up-Regulation
OTO - NOTNLM
OT  - Apoptosis
OT  - CAM-DR
OT  - CHD1L
OT  - Multiple myeloma
EDAT- 2016/06/04 06:00
MHDA- 2017/07/18 06:00
CRDT- 2016/06/04 06:00
PHST- 2015/11/01 00:00 [received]
PHST- 2016/04/16 00:00 [revised]
PHST- 2016/05/12 00:00 [accepted]
PHST- 2016/06/04 06:00 [entrez]
PHST- 2016/06/04 06:00 [pubmed]
PHST- 2017/07/18 06:00 [medline]
AID - S0145-2126(16)30107-2 [pii]
AID - 10.1016/j.leukres.2016.05.007 [doi]
PST - ppublish
SO  - Leuk Res. 2016 Aug;47:54-62. doi: 10.1016/j.leukres.2016.05.007. Epub 2016 May 
      12.