PMID- 27259981
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1862
IP  - 9
DP  - 2016 Sep
TI  - Mixed - Lineage Protein kinases (MLKs) in inflammation, metabolism, and other 
      disease states.
PG  - 1581-6
LID - S0925-4439(16)30139-9 [pii]
LID - 10.1016/j.bbadis.2016.05.022 [doi]
AB  - Mixed lineage kinases, or MLKs, are members of the MAP kinase kinase kinase 
      (MAP3K) family, which were originally identified among the activators of the 
      major stress-dependent mitogen activated protein kinases (MAPKs), JNK and p38. 
      During stress, the activation of JNK and p38 kinases targets several essential 
      downstream substrates that react in a specific manner to the unique stressor and 
      thus determine the fate of the cell in response to a particular challenge. 
      Recently, the MLK family was identified as a specific modulator of JNK and p38 
      signaling in metabolic syndrome. Moreover, the MLK family of kinases appears to 
      be involved in a very wide spectrum of disorders. This review discusses the newly 
      identified functions of MLKs in multiple diseases including metabolic disorders, 
      inflammation, cancer, and neurological diseases.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Craige, Siobhan M
AU  - Craige SM
AD  - Division of Cardiovascular Medicine, Department of Medicine, University of 
      Massachusetts Medical School, Worcester, MA 01605, United States.
FAU - Reif, Michaella M
AU  - Reif MM
AD  - Division of Cardiovascular Medicine, Department of Medicine, University of 
      Massachusetts Medical School, Worcester, MA 01605, United States.
FAU - Kant, Shashi
AU  - Kant S
AD  - Division of Cardiovascular Medicine, Department of Medicine, University of 
      Massachusetts Medical School, Worcester, MA 01605, United States. Electronic 
      address: shashi.kant@umassmed.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160531
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Cytokines)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/enzymology
MH  - Cytokines/biosynthesis
MH  - Humans
MH  - Inflammation/*enzymology
MH  - Insulin Resistance/physiology
MH  - Liver Diseases/enzymology
MH  - MAP Kinase Kinase Kinases/chemistry/*metabolism
MH  - MAP Kinase Signaling System
MH  - Metabolic Diseases/*enzymology
MH  - Metabolic Syndrome/enzymology
MH  - Neoplasms/enzymology
MH  - Nervous System Diseases/enzymology
MH  - Obesity/enzymology
MH  - Stress, Physiological
OTO - NOTNLM
OT  - Disease
OT  - Inflammation
OT  - Insulin resistance
OT  - Kinase
OT  - Metabolism
OT  - Mixed-lineage kinase
OT  - Signal transduction
EDAT- 2016/06/05 06:00
MHDA- 2019/01/29 06:00
CRDT- 2016/06/05 06:00
PHST- 2016/02/27 00:00 [received]
PHST- 2016/05/26 00:00 [revised]
PHST- 2016/05/27 00:00 [accepted]
PHST- 2016/06/05 06:00 [entrez]
PHST- 2016/06/05 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
AID - S0925-4439(16)30139-9 [pii]
AID - 10.1016/j.bbadis.2016.05.022 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2016 Sep;1862(9):1581-6. doi: 10.1016/j.bbadis.2016.05.022. 
      Epub 2016 May 31.