PMID- 27260561
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20220316
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 86
DP  - 2016 Dec 15
TI  - Energetic interventions for healthspan and resiliency with aging.
PG  - 73-83
LID - S0531-5565(16)30147-4 [pii]
LID - 10.1016/j.exger.2016.05.012 [doi]
AB  - Several behavioral and pharmacological strategies improve longevity, which is 
      indicative of delayed organismal aging, with the most effective interventions 
      extending both life- and healthspan. In free living creatures, maintaining health 
      and function into old age requires resilience against a multitude of stressors. 
      Conversely, in experimental settings, conventional housing of rodents limits 
      exposure to such challenges, thereby obscuring an accurate assessment of 
      resilience. Caloric restriction (CR) and exercise, as well as pharmacologic 
      strategies (resveratrol, rapamycin, metformin, senolytics), are well established 
      to improve indices of health and aging, but some paradoxical effects have been 
      observed on resilience. For instance, CR potently retards the onset of 
      age-related diseases, and improves lifespan to a greater extent than exercise in 
      a variety of models. However, exercise has proven more consistently beneficial to 
      organismal resilience against a broad array of stressors, including infections, 
      surgery, wound healing and frailty. CR can improve cellular stress defenses and 
      protect from frailty, but also impairs the response to infections, bed rest and 
      healing. How an intervention will impact not only longevity, health and function, 
      but also resiliency, is critical to better understanding translational 
      implications. Thus, organismal robustness represents a critical, albeit 
      understudied aspect of aging, which needs more careful attention in order to 
      better inform on how putative age-delaying strategies will impact preservation of 
      health and function in response to stressors with aging in humans.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Huffman, Derek M
AU  - Huffman DM
AD  - Department of Molecular Pharmacology and Medicine, Albert Einstein College of 
      Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College 
      of Medicine, Bronx, NY, USA. Electronic address: derek.huffman@einstein.yu.edu.
FAU - Schafer, Marissa J
AU  - Schafer MJ
AD  - Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
FAU - LeBrasseur, Nathan K
AU  - LeBrasseur NK
AD  - Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
LA  - eng
GR  - P01 AG041122/AG/NIA NIH HHS/United States
GR  - P30 AG038072/AG/NIA NIH HHS/United States
GR  - P30 DK020541/DK/NIDDK NIH HHS/United States
GR  - R00 AG037574/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20160531
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Stilbenes)
RN  - 9100L32L2N (Metformin)
RN  - Q369O8926L (Resveratrol)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Aging/drug effects/*physiology
MH  - Caloric Restriction/*methods
MH  - *Diet
MH  - Energy Intake/*physiology
MH  - Exercise/physiology
MH  - Female
MH  - Humans
MH  - Longevity/*physiology
MH  - Male
MH  - Metformin/therapeutic use
MH  - Resveratrol
MH  - Sirolimus/therapeutic use
MH  - Stilbenes/therapeutic use
PMC - PMC5133182
MID - NIHMS809124
OTO - NOTNLM
OT  - Aging
OT  - Caloric restriction
OT  - Diet
OT  - Exercise
OT  - Metformin
OT  - Rapamycin
OT  - Resiliency
OT  - Resveratrol
OT  - Robustness
OT  - Senolytics
EDAT- 2016/06/05 06:00
MHDA- 2017/10/11 06:00
PMCR- 2017/12/15
CRDT- 2016/06/05 06:00
PHST- 2016/01/20 00:00 [received]
PHST- 2016/05/03 00:00 [revised]
PHST- 2016/05/24 00:00 [accepted]
PHST- 2016/06/05 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2016/06/05 06:00 [entrez]
PHST- 2017/12/15 00:00 [pmc-release]
AID - S0531-5565(16)30147-4 [pii]
AID - 10.1016/j.exger.2016.05.012 [doi]
PST - ppublish
SO  - Exp Gerontol. 2016 Dec 15;86:73-83. doi: 10.1016/j.exger.2016.05.012. Epub 2016 
      May 31.