PMID- 27261213 OWN - NLM STAT- MEDLINE DCOM- 20170711 LR - 20180202 IS - 1873-7544 (Electronic) IS - 0306-4522 (Linking) VI - 330 DP - 2016 Aug 25 TI - New insights on amygdala: Basomedial amygdala regulates the physiological response to social novelty. PG - 181-90 LID - S0306-4522(16)30212-3 [pii] LID - 10.1016/j.neuroscience.2016.05.053 [doi] AB - The amygdala has been associated with a variety of functions linked to physiological, behavioral and endocrine responses during emotional situations. This brain region is comprised of multiple sub-nuclei. These sub-nuclei belong to the same structure, but may be involved in different functions, thereby making the study of each sub-nuclei important. Yet, the involvement of the basomedial amygdala (BMA) in the regulation of emotional states has yet to be defined. Therefore, the aim of our study was to investigate the regulatory role of the BMA on the responses evoked during a social novelty model and whether the regulatory role depended on an interaction with the dorsomedial hypothalamus (DMH). Our results showed that the chemical inhibition of the BMA by the microinjection of muscimol (gamma-aminobutyric acid (GABAA) agonist) promoted increases in mean arterial pressure (MAP) and heart rate (HR), whereas the chemical inhibition of regions near the BMA did not induce such cardiovascular changes. In contrast, the BMA chemical activation by the bilateral microinjection of bicuculline methiodide (BMI; GABAA antagonist), blocked the increases in MAP and HR observed when an intruder rat was suddenly introduced into the cage of a resident rat, and confined to the small cage for 15min. Additionally, the increase in HR and MAP induced by BMA inhibition were eliminated by DMH chemical inhibition. Thus, our data reveal that the BMA is under continuous GABAergic influence, and that its hyperactivation can reduce the physiological response induced by a social novelty condition, possibly by inhibiting DMH neurons. CI - Copyright (c) 2016 IBRO. Published by Elsevier Ltd. All rights reserved. FAU - Mesquita, Laura Tavares AU - Mesquita LT AD - Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil. Electronic address: laugbatista@yahoo.com.br. FAU - Abreu, Aline Rezende AU - Abreu AR AD - Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil. Electronic address: alirriba@yahoo.com.br. FAU - de Abreu, Alessandra Rezende AU - de Abreu AR AD - Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil. Electronic address: arrabreu@gmail.com. FAU - de Souza, Aline Arlindo AU - de Souza AA AD - Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil. Electronic address: alinearlindo.nut@gmail.com. FAU - de Noronha, Sylvana Rendeiro AU - de Noronha SR AD - Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil. Electronic address: sylvana.nut@gmail.com. FAU - Silva, Fernanda Cacilda AU - Silva FC AD - Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil. Electronic address: fernandasilva_nut@yahoo.com.br. FAU - Campos, Glenda Siqueira Viggiano AU - Campos GS AD - Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil. Electronic address: glendasiqueira@hotmail.com. FAU - Chianca, Deoclecio Alves Jr AU - Chianca DA Jr AD - Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil. Electronic address: deochianca@gmail.com. FAU - de Menezes, Rodrigo Cunha AU - de Menezes RC AD - Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil. Electronic address: rodrigo.menezes@iceb.ufop.br. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160531 PL - United States TA - Neuroscience JT - Neuroscience JID - 7605074 RN - 0 (GABA-A Receptor Agonists) RN - 0 (GABA-A Receptor Antagonists) RN - 0 (Receptors, GABA-A) RN - 2763-96-4 (Muscimol) RN - 40709-69-1 (bicuculline methiodide) RN - Y37615DVKC (Bicuculline) SB - IM MH - Amygdala/drug effects/*metabolism MH - Animals MH - Bicuculline/analogs & derivatives/pharmacology MH - Blood Pressure/drug effects/physiology MH - GABA-A Receptor Agonists/pharmacology MH - GABA-A Receptor Antagonists/pharmacology MH - Heart Rate/drug effects/physiology MH - Male MH - Muscimol/pharmacology MH - Rats, Wistar MH - Receptors, GABA-A/*metabolism MH - *Social Perception MH - Stress, Psychological/drug therapy/metabolism OTO - NOTNLM OT - dorsomedial hypothalamus OT - intruder rat OT - social novelty basomedial amygdala EDAT- 2016/06/05 06:00 MHDA- 2017/07/14 06:00 CRDT- 2016/06/05 06:00 PHST- 2016/01/21 00:00 [received] PHST- 2016/05/25 00:00 [revised] PHST- 2016/05/26 00:00 [accepted] PHST- 2016/06/05 06:00 [entrez] PHST- 2016/06/05 06:00 [pubmed] PHST- 2017/07/14 06:00 [medline] AID - S0306-4522(16)30212-3 [pii] AID - 10.1016/j.neuroscience.2016.05.053 [doi] PST - ppublish SO - Neuroscience. 2016 Aug 25;330:181-90. doi: 10.1016/j.neuroscience.2016.05.053. Epub 2016 May 31.