PMID- 27262229
OWN - NLM
STAT- MEDLINE
DCOM- 20170123
LR  - 20170123
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 45
IP  - 11
DP  - 2016 Nov
TI  - [Management of gastrinoma].
PG  - 986-991
LID - S0755-4982(16)30069-0 [pii]
LID - 10.1016/j.lpm.2016.04.012 [doi]
AB  - Gastrinoma is a very rare tumor leading to gastrin hypersecretion and 
      characterised by Zollinger-Ellisson syndrome (ZES) i.e. severe gastric and 
      duodenal ulceration and profuse diarrhea. This disease can be sporadic or 
      familial within a multiple endocrine neoplasia type 1 (MEN-1) syndrome. Diagnosis 
      is based on hypergastrinemia/hypercholrhydria. Tumors are usually located in the 
      duodeno-pancreas. Preoperative tumor location by CT, echoendoscopy and fibroscopy 
      is not always possible because of the small size of the lesion that are 
      frequently multiple. The aim of gastrinoma treatment is 1/to control the hormonal 
      hypersecretion 2/to remove the neoplasm when it is possible. Surgery is the only 
      chance to cure. Gastrinoma is a slow-growing tumor, and overall survival is good 
      with a median survival above 10years and a 5-year survival above 80 % in 
      surgically resected patients. Recurrence is frequent, a biochemical recurrence is 
      observed in 65 % of cases and morphological recurrence in 40 % of patients at 
      2years. Metastases are associated with a dismal prognosis.
CI  - Copyright (c) 2016 Elsevier Masson SAS. All rights reserved.
FAU - Hain, Elisabeth
AU  - Hain E
AD  - AP-HP, hopital Cochin, service de chirurgie digestive hepato-biliaire et 
      endocrienne, Paris, France.
FAU - Coriat, Romain
AU  - Coriat R
AD  - AP-HP, hopital Cochin, service de gastroenterologie, 27, rue du 
      Faubourg-Saint-Jacques, 75014 Paris, France; Universite Paris Descartes, 12, rue 
      de l'Ecole-de-Medecine, 75006 Paris, France.
FAU - Dousset, Bertrand
AU  - Dousset B
AD  - AP-HP, hopital Cochin, service de chirurgie digestive hepato-biliaire et 
      endocrienne, Paris, France; Universite Paris Descartes, 12, rue de 
      l'Ecole-de-Medecine, 75006 Paris, France.
FAU - Gaujoux, Sebastien
AU  - Gaujoux S
AD  - AP-HP, hopital Cochin, service de chirurgie digestive hepato-biliaire et 
      endocrienne, Paris, France; Universite Paris Descartes, 12, rue de 
      l'Ecole-de-Medecine, 75006 Paris, France. Electronic address: 
      sebastien.gaujoux@aphp.fr.
LA  - fre
PT  - Journal Article
PT  - Review
TT  - Prise en charge du gastrinome.
DEP - 20160601
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Diagnostic Imaging
MH  - Gastrinoma/diagnosis/mortality/*surgery
MH  - Humans
MH  - Pancreatic Neoplasms/diagnosis/mortality/*surgery
MH  - Prognosis
MH  - Survival Analysis
MH  - Zollinger-Ellison Syndrome/diagnosis/mortality/surgery
EDAT- 2016/06/06 06:00
MHDA- 2017/01/24 06:00
CRDT- 2016/06/06 06:00
PHST- 2016/04/18 00:00 [received]
PHST- 2016/04/19 00:00 [accepted]
PHST- 2016/06/06 06:00 [pubmed]
PHST- 2017/01/24 06:00 [medline]
PHST- 2016/06/06 06:00 [entrez]
AID - S0755-4982(16)30069-0 [pii]
AID - 10.1016/j.lpm.2016.04.012 [doi]
PST - ppublish
SO  - Presse Med. 2016 Nov;45(11):986-991. doi: 10.1016/j.lpm.2016.04.012. Epub 2016 
      Jun 1.