PMID- 27262928
OWN - NLM
STAT- MEDLINE
DCOM- 20171128
LR  - 20221207
IS  - 1879-0542 (Electronic)
IS  - 0165-2478 (Linking)
VI  - 176
DP  - 2016 Aug
TI  - HLA-G coding region and 3'untranslated region (3'UTR) in two Chinese Han 
      populations.
PG  - 65-71
LID - S0165-2478(16)30098-0 [pii]
LID - 10.1016/j.imlet.2016.05.017 [doi]
AB  - In this study, exons 2-4 and 3'untranslated region (3'UTR) of human leukocyte 
      antigen (HLA)-G gene were investigated for 201 and 104 healthy unrelated Han 
      samples recruited from Hunan Province, southern China and central Inner Mongolia 
      Autonomous Region, northern China, respectively, using sequence-based typing and 
      cloning methods. Totally 12 HLA-G alleles in the coding region, 9 variable sites 
      in 3'UTR, 8 3'UTR haplotypes and 15 HLA-G extended haplotypes (EHs) incorporating 
      the coding region and 3'UTR were observed. Very strong linkage disequilibrium 
      (LD) was observed between HLA-A and HLA-G, and between HLA-G coding region and 
      3'UTR in each population (all global P=0.0000). Seven HLA-A-G haplotypes showed 
      significant LD in both populations. Three HLA-G alleles in the coding region, 4 
      polymorphic sites in the 3'UTR, 3 3'UTR haplotypes and 4 HLA-G EHs differed 
      significantly in their distributions between the 2 Chinese Han populations (all 
      P</=0.0001). There was evidence for balancing selection acting on HLA-G 3'UTR 
      positions +3010, +3142 and +3187 in the two populations. The NJ dendrograms 
      demonstrated the existence of two basic HLA-G lineages and indicated that, 
      HLA-G*01:01:01, the most common HLA-G allele, formed a separate lineage from 
      other alleles. Our results shed new lights into HLA-G genetics among Chinese Han 
      populations. The findings reported here are of importance for future studies 
      related to post-transcriptional regulation of HLA-G allelic expression and the 
      potential role of HLA-G in disease association in populations of Chinese 
      ancestry.
CI  - Copyright (c) 2016 European Federation of Immunological Societies. Published by 
      Elsevier B.V. All rights reserved.
FAU - Wang, Wen Yi
AU  - Wang WY
AD  - Immunogenetics Research Group, Department of Immunology, College of Basic Medical 
      Sciences, Central South University, Changsha, Hunan, China.
FAU - Tian, Wei
AU  - Tian W
AD  - Immunogenetics Research Group, Department of Immunology, College of Basic Medical 
      Sciences, Central South University, Changsha, Hunan, China; Laboratory of 
      Cellular and Molecular Biology, College of Basic Medical Sciences, Central South 
      University, Changsha, Hunan, China. Electronic address: tianwei6@csu.edu.cn.
FAU - Liu, Xue Xiang
AU  - Liu XX
AD  - Immunogenetics Research Group, Department of Immunology, College of Basic Medical 
      Sciences, Central South University, Changsha, Hunan, China.
FAU - Li, Li Xin
AU  - Li LX
AD  - Laboratory of Cellular and Molecular Biology, College of Basic Medical Sciences, 
      Central South University, Changsha, Hunan, China.
LA  - eng
PT  - Journal Article
DEP - 20160602
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (3' Untranslated Regions)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - 3' Untranslated Regions/*genetics
MH  - Adult
MH  - *Asian People
MH  - China
MH  - Evolution, Molecular
MH  - Female
MH  - Gene Expression Regulation
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-G Antigens/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Open Reading Frames/*genetics
MH  - Polymorphism, Genetic
MH  - Selection, Genetic
OTO - NOTNLM
OT  - 3'Untranslated region
OT  - Chinese Han population
OT  - HLA-G
OT  - Linkage disequilibrium
OT  - Sequence-based typing
EDAT- 2016/06/06 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/06/06 06:00
PHST- 2016/03/10 00:00 [received]
PHST- 2016/05/02 00:00 [revised]
PHST- 2016/05/30 00:00 [accepted]
PHST- 2016/06/06 06:00 [entrez]
PHST- 2016/06/06 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - S0165-2478(16)30098-0 [pii]
AID - 10.1016/j.imlet.2016.05.017 [doi]
PST - ppublish
SO  - Immunol Lett. 2016 Aug;176:65-71. doi: 10.1016/j.imlet.2016.05.017. Epub 2016 Jun 
      2.