PMID- 27263444
OWN - NLM
STAT- MEDLINE
DCOM- 20180502
LR  - 20190111
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Jun 6
TI  - Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting 
      and PDT/PTT agent for cancer therapy.
PG  - 27421
LID - 10.1038/srep27421 [doi]
LID - 27421
AB  - Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique 
      advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one 
      generally needs two lasers with different wavelengths. Near-infrared dye IR-780 
      could be used as photosensitizer both for PTT and PDT, but its lipophilicity 
      limits its practical use and in vivo efficiency. Herein, a simple multifunctional 
      IR780-loaded nanoplatform based on transferrin was developed for targeted imaging 
      and phototherapy of cancer compatible with a single-NIR-laser irradiation. The 
      self-assembled transferrin-IR780 nanoparticles (Tf-IR780 NPs) exhibited narrow 
      size distribution, good photo-stability, and encouraging photothermal performance 
      with enhanced generation of ROS under laser irradiation. Following intravenous 
      injection, Tf-IR780 NPs had a high tumor-to-background ratio in CT26 
      tumor-bearing mice. Treatment with Tf-IR780 NPs resulted in significant tumor 
      suppression. Overall, the Tf-IR780 NPs show notable targeting and theranostic 
      potential in cancer therapy.
FAU - Wang, Kaikai
AU  - Wang K
AD  - State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing 
      University, Nanjing 210093, China.
AD  - State Key Laboratory of Natural Medicines, China Pharmaceutical University, 
      Nanjing 210009, China.
FAU - Zhang, Yifan
AU  - Zhang Y
AD  - State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing 
      University, Nanjing 210093, China.
FAU - Wang, Juan
AU  - Wang J
AD  - State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing 
      University, Nanjing 210093, China.
FAU - Yuan, Ahu
AU  - Yuan A
AD  - State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing 
      University, Nanjing 210093, China.
FAU - Sun, Minjie
AU  - Sun M
AD  - State Key Laboratory of Natural Medicines, China Pharmaceutical University, 
      Nanjing 210009, China.
FAU - Wu, Jinhui
AU  - Wu J
AD  - State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing 
      University, Nanjing 210093, China.
AD  - State Key Laboratory of Natural Medicines, China Pharmaceutical University, 
      Nanjing 210009, China.
AD  - Institute of Drug R, Medical School of Nanjing University, Nanjing 210093, China.
AD  - Jiangsu R Platform for Controlled &Targeted Drug Delivery, Nanjing University, 
      Nanjing 210093, China.
FAU - Hu, Yiqiao
AU  - Hu Y
AD  - State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing 
      University, Nanjing 210093, China.
AD  - Institute of Drug R, Medical School of Nanjing University, Nanjing 210093, China.
AD  - Jiangsu R Platform for Controlled &Targeted Drug Delivery, Nanjing University, 
      Nanjing 210093, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160606
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 
      (2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium)
RN  - 0 (Indoles)
RN  - 0 (Transferrin)
SB  - IM
MH  - Animals
MH  - Hyperthermia, Induced/*methods
MH  - Indoles/pharmacology/therapeutic use
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Nanoparticles
MH  - Neoplasms/drug therapy/*therapy
MH  - *Photochemotherapy
MH  - Phototherapy/*methods
MH  - Spectrophotometry, Ultraviolet
MH  - Transferrin/*chemistry
PMC - PMC4899881
EDAT- 2016/06/07 06:00
MHDA- 2018/05/03 06:00
PMCR- 2016/06/06
CRDT- 2016/06/07 06:00
PHST- 2016/03/31 00:00 [received]
PHST- 2016/05/18 00:00 [accepted]
PHST- 2016/06/07 06:00 [entrez]
PHST- 2016/06/07 06:00 [pubmed]
PHST- 2018/05/03 06:00 [medline]
PHST- 2016/06/06 00:00 [pmc-release]
AID - srep27421 [pii]
AID - 10.1038/srep27421 [doi]
PST - epublish
SO  - Sci Rep. 2016 Jun 6;6:27421. doi: 10.1038/srep27421.