PMID- 27264365
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160829
LR  - 20160606
IS  - 1300-7777 (Print)
IS  - 1300-7777 (Linking)
VI  - 28
IP  - 3
DP  - 2011 Sep 5
TI  - Variant Philadelphia translocations with different breakpoints in six chronic 
      myeloid leukemia patients.
PG  - 186-92
LID - 10.5152/tjh.2011.52 [doi]
AB  - OBJECTIVE: The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11) 
      translocation, is observed in ~90% of patients with chronic myeloid leukemia 
      (CML). Variant Ph translocations are observed in 5%-10% of CML patients. In 
      variant translocations 3 and possibly more chromosomes are involved. Herein we 
      report 6 CML patients with variant Ph translocations. METHODS: Bone marrow 
      samples were examined using conventional cytogenetic meth ods. Fluorescence in 
      situ hybridization (FISH) with whole-chromosome paints and BCR-ABL 1D probes were 
      used to confirm and/or complement the findings, and identify rearrangements 
      beyond the resolution of conventional cytogenetic methods. RESULTS: Variant Ph 
      translocations in the 6 patients were as follows: t(7;22)(p22;q11), 
      t(9;22;15)(q34;q11;q22), t(15;22)(p11;q11), t(1;9;22;3)(q24;q34;q11;q21), 
      t(12;22)(p13;q11), and t(4;8;9;22)(q11;q13;q34;q11). CONCLUSION: Among the 
      patients, 3 had simple and 3 had complex variant Ph translocations. Two of the 
      presented cases had variant Ph chromosomes not previously described, 1 of which 
      had a new complex Ph translocation involving chromosomes 1, 3, 9, 22, and 
      t(1;9;22;3)(q24;q34;q11;q21) apart from a clone with a classical Ph, and the 
      other case had variant Ph translocation with chromosomes 4, 8, 9, and 22, and 
      t(4;8;9;22)(q11;q13;q34;q11) full complex translocation. Number of studies 
      reported that some patients with variant Ph translocation were poor responders to 
      imatinib. All of our patients with variant Ph translocations had suboptimal 
      responses to imatinib, denoting a poor prognosis also. Variant Ph translocations 
      may be important as they are associated with prognosis and therapy for CML 
      patients.
FAU - Kuru, Dilhan
AU  - Kuru D
AD  - Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul 
      University, Istanbul, Turkey Phone: +90 212 414 30 34 E-mail: 
      dilhank@istanbul.edu.tr.
FAU - Tarkan Arguden, Yelda
AU  - Tarkan Arguden Y
FAU - Ar, Muhlis Cem
AU  - Ar MC
FAU - Cirakoglu, Ayse
AU  - Cirakoglu A
FAU - Ongoren, Seniz
AU  - Ongoren S
FAU - Yilmaz, Sukriye
AU  - Yilmaz S
FAU - Eskazan, Ahmet Emre
AU  - Eskazan AE
FAU - Deviren, Ayhan
AU  - Deviren A
FAU - Soysal, Teoman
AU  - Soysal T
FAU - Hacihanefioglu, Seniha
AU  - Hacihanefioglu S
FAU - Ulku, Birsen
AU  - Ulku B
LA  - eng
PT  - Journal Article
TT  - Alti Kronik miyeloid losemi olgusunda farkli kirik noktali varyant Philadelphia 
      translokasyonlari.
PL  - Turkey
TA  - Turk J Haematol
JT  - Turkish journal of haematology : official journal of Turkish Society of 
      Haematology
JID - 9606065
EDAT- 2011/09/05 00:00
MHDA- 2011/09/05 00:01
CRDT- 2016/06/07 06:00
PHST- 2016/06/07 06:00 [entrez]
PHST- 2011/09/05 00:00 [pubmed]
PHST- 2011/09/05 00:01 [medline]
AID - 10.5152/tjh.2011.52 [doi]
PST - ppublish
SO  - Turk J Haematol. 2011 Sep 5;28(3):186-92. doi: 10.5152/tjh.2011.52.