PMID- 27264435
OWN - NLM
STAT- MEDLINE
DCOM- 20170817
LR  - 20180409
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 148
DP  - 2016 Sep
TI  - Serotonin antagonists fail to alter MDMA self-administration in rats.
PG  - 38-45
LID - S0091-3057(16)30101-0 [pii]
LID - 10.1016/j.pbb.2016.06.002 [doi]
AB  - Acute exposure to +/-3,4-methylenedioxymethamphetamine (MDMA) preferentially 
      increases release of serotonin (5-HT), and a role of 5-HT in many of the 
      behavioral effects of acute exposure to MDMA has been demonstrated. A role of 
      5-HT in MDMA self-administration in rats has not, however, been adequately 
      determined. Therefore, the present study measured the effect of pharmacological 
      manipulation of some 5-HT receptor subtypes on self-administration of MDMA. Rats 
      received extensive experience with self-administered MDMA prior to tests with 
      5-HT ligands. Doses of the 5-HT1A antagonist, WAY 100635 (0.1-1.0mg/kg), 5-HT1B 
      antagonist, GR 127935 (1.0-3.0mg/kg), and the 5-HT2A antagonist, ketanserin 
      (1.0-3.0mg/kg) that have previously been shown to decrease self-administration of 
      other psychostimulants and that decreased MDMA-produced hyperactivity in the 
      present study did not alter MDMA self-administration. Experimenter-administered 
      injections of MDMA (10.0mg/kg, ip) reinstated extinguished drug-taking behavior, 
      but this also was not decreased by any of the antagonists. In contrast, both WAY 
      100635 and ketanserin, but not GR 127935, decreased cocaine-produced drug seeking 
      in rats that had been trained to self-administered cocaine. The 5-HT1A agonist, 
      8-OH-DPAT (0.1-1.0mg/kg), but not the 5-HT1B/1A agonist, RU 24969 (0.3-3.0mg/kg), 
      decreased drug-seeking produced by the reintroduction of a light stimulus that 
      had been paired with self-administered MDMA infusions. These findings suggest a 
      limited role of activation of 5-HT1A, 5-HT1B or 5-HT2 receptor mechanisms in MDMA 
      self-administration or in MDMA-produced drug-seeking following extinction. The 
      data suggest, however, that 5-HT1A agonists inhibit cue-induced drug-seeking 
      following extinction of MDMA self-administration and might, therefore, be useful 
      adjuncts to therapies to limit relapse to MDMA use.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Schenk, Susan
AU  - Schenk S
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand. 
      Electronic address: susan.schenk@vuw.ac.nz.
FAU - Foote, Jason
AU  - Foote J
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
FAU - Aronsen, Dane
AU  - Aronsen D
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
FAU - Bukholt, Natasha
AU  - Bukholt N
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
FAU - Highgate, Quenten
AU  - Highgate Q
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
FAU - Van de Wetering, Ross
AU  - Van de Wetering R
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
FAU - Webster, Jeremy
AU  - Webster J
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160602
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Oxadiazoles)
RN  - 0 (Piperazines)
RN  - 0 (Pyridines)
RN  - 0 (Serotonin Antagonists)
RN  - 2LLH6CEB40 (GR 127935)
RN  - 71IH826FEG 
      (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - 97F9DE4CT4 (Ketanserin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Animals
MH  - Drug-Seeking Behavior/drug effects
MH  - Extinction, Psychological
MH  - Ketanserin/pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Oxadiazoles/pharmacology
MH  - Piperazines/pharmacology
MH  - Pyridines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Self Administration
MH  - Serotonin Antagonists/*pharmacology
OTO - NOTNLM
OT  - Hyperactivity
OT  - MDMA
OT  - Reinstatement
OT  - Self-administration
OT  - Serotonin receptors
EDAT- 2016/06/07 06:00
MHDA- 2017/08/18 06:00
CRDT- 2016/06/07 06:00
PHST- 2016/02/29 00:00 [received]
PHST- 2016/05/24 00:00 [revised]
PHST- 2016/06/01 00:00 [accepted]
PHST- 2016/06/07 06:00 [entrez]
PHST- 2016/06/07 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
AID - S0091-3057(16)30101-0 [pii]
AID - 10.1016/j.pbb.2016.06.002 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2016 Sep;148:38-45. doi: 10.1016/j.pbb.2016.06.002. Epub 
      2016 Jun 2.