PMID- 27264606
OWN - NLM
STAT- MEDLINE
DCOM- 20170110
LR  - 20170111
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Linking)
VI  - 166
IP  - 1
DP  - 2016 Jun 30
TI  - Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded 
      Proteins.
PG  - 140-51
LID - S0092-8674(16)30554-2 [pii]
LID - 10.1016/j.cell.2016.05.006 [doi]
AB  - Caloric restriction (CR) extends the lifespan of flies, worms, and yeast by 
      counteracting age-related oxidation of H2O2-scavenging peroxiredoxins (Prxs). 
      Here, we show that increased dosage of the major cytosolic Prx in yeast, Tsa1, 
      extends lifespan in an Hsp70 chaperone-dependent and CR-independent manner 
      without increasing H2O2 scavenging or genome stability. We found that Tsa1 and 
      Hsp70 physically interact and that hyperoxidation of Tsa1 by H2O2 is required for 
      the recruitment of the Hsp70 chaperones and the Hsp104 disaggregase to misfolded 
      and aggregated proteins during aging, but not heat stress. Tsa1 counteracted the 
      accumulation of ubiquitinated aggregates during aging and the reduction of 
      hyperoxidized Tsa1 by sulfiredoxin facilitated clearance of H2O2-generated 
      aggregates. The data reveal a conceptually new role for H2O2 signaling in 
      proteostasis and lifespan control and shed new light on the selective benefits 
      endowed to eukaryotic peroxiredoxins by their reversible hyperoxidation.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Hanzen, Sarah
AU  - Hanzen S
AD  - Department of Chemistry and Molecular Biology (CMB), University of Gothenburg, 
      Medicinaregatan 9C, 413 90 Goteborg, Sweden; Institute of Biomedicine, 
      Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 7A, 413 90 
      Goteborg, Sweden.
FAU - Vielfort, Katarina
AU  - Vielfort K
AD  - Department of Chemistry and Molecular Biology (CMB), University of Gothenburg, 
      Medicinaregatan 9C, 413 90 Goteborg, Sweden; Institute of Biomedicine, 
      Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 7A, 413 90 
      Goteborg, Sweden.
FAU - Yang, Junsheng
AU  - Yang J
AD  - Department of Chemistry and Molecular Biology (CMB), University of Gothenburg, 
      Medicinaregatan 9C, 413 90 Goteborg, Sweden.
FAU - Roger, Friederike
AU  - Roger F
AD  - Department of Chemistry and Molecular Biology (CMB), University of Gothenburg, 
      Medicinaregatan 9C, 413 90 Goteborg, Sweden.
FAU - Andersson, Veronica
AU  - Andersson V
AD  - Department of Chemistry and Molecular Biology (CMB), University of Gothenburg, 
      Medicinaregatan 9C, 413 90 Goteborg, Sweden.
FAU - Zamarbide-Fores, Sara
AU  - Zamarbide-Fores S
AD  - Department of Chemistry and Molecular Biology (CMB), University of Gothenburg, 
      Medicinaregatan 9C, 413 90 Goteborg, Sweden.
FAU - Andersson, Rebecca
AU  - Andersson R
AD  - Department of Chemistry and Molecular Biology (CMB), University of Gothenburg, 
      Medicinaregatan 9C, 413 90 Goteborg, Sweden; Institute of Biomedicine, 
      Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 7A, 413 90 
      Goteborg, Sweden.
FAU - Malm, Lisa
AU  - Malm L
AD  - Department of Chemistry and Molecular Biology (CMB), University of Gothenburg, 
      Medicinaregatan 9C, 413 90 Goteborg, Sweden.
FAU - Palais, Gael
AU  - Palais G
AD  - Oxidative Stress and Cancer, IBITECS, SBIGEM, CEA-Saclay, 91191 Gif-sur-Yvette, 
      France.
FAU - Biteau, Benoit
AU  - Biteau B
AD  - Oxidative Stress and Cancer, IBITECS, SBIGEM, CEA-Saclay, 91191 Gif-sur-Yvette, 
      France; School of Medicine and Dentistry, University of Rochester Medical Center, 
      601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA.
FAU - Liu, Beidong
AU  - Liu B
AD  - Department of Chemistry and Molecular Biology (CMB), University of Gothenburg, 
      Medicinaregatan 9C, 413 90 Goteborg, Sweden.
FAU - Toledano, Michel B
AU  - Toledano MB
AD  - Oxidative Stress and Cancer, IBITECS, SBIGEM, CEA-Saclay, 91191 Gif-sur-Yvette, 
      France.
FAU - Molin, Mikael
AU  - Molin M
AD  - Department of Chemistry and Molecular Biology (CMB), University of Gothenburg, 
      Medicinaregatan 9C, 413 90 Goteborg, Sweden. Electronic address: 
      mikael.molin@cmb.gu.se.
FAU - Nystrom, Thomas
AU  - Nystrom T
AD  - Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 
      Medicinaregatan 7A, 413 90 Goteborg, Sweden. Electronic address: 
      thomas.nystrom@cmb.gu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160602
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Protein Aggregates)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 143012-44-6 (HsP104 protein, S cerevisiae)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.- (Peroxidases)
RN  - EC 1.11.1.- (Tsa1 protein, S cerevisiae)
SB  - IM
MH  - Animals
MH  - Caloric Restriction
MH  - Genomic Instability
MH  - HSP70 Heat-Shock Proteins/*metabolism
MH  - Heat-Shock Proteins/metabolism
MH  - Humans
MH  - Hydrogen Peroxide/*metabolism
MH  - *Longevity
MH  - Oxidation-Reduction
MH  - Peroxidases/*metabolism
MH  - Protein Aggregates
MH  - *Protein Folding
MH  - Saccharomyces cerevisiae/cytology/*metabolism
MH  - Saccharomyces cerevisiae Proteins/*metabolism
MH  - Signal Transduction
EDAT- 2016/06/07 06:00
MHDA- 2017/01/11 06:00
CRDT- 2016/06/07 06:00
PHST- 2015/08/26 00:00 [received]
PHST- 2015/12/23 00:00 [revised]
PHST- 2016/05/01 00:00 [accepted]
PHST- 2016/06/07 06:00 [entrez]
PHST- 2016/06/07 06:00 [pubmed]
PHST- 2017/01/11 06:00 [medline]
AID - S0092-8674(16)30554-2 [pii]
AID - 10.1016/j.cell.2016.05.006 [doi]
PST - ppublish
SO  - Cell. 2016 Jun 30;166(1):140-51. doi: 10.1016/j.cell.2016.05.006. Epub 2016 Jun 
      2.