PMID- 27264874
OWN - NLM
STAT- MEDLINE
DCOM- 20170306
LR  - 20170723
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 44
IP  - 1
DP  - 2017 Feb
TI  - Successful treatment of radiation-induced mucositis with proton pump inhibitor 
      administration: A report of two laryngeal cancer cases.
PG  - 122-125
LID - S0385-8146(16)30155-9 [pii]
LID - 10.1016/j.anl.2016.05.006 [doi]
AB  - Presently, the relationship between laryngopharyngeal reflux (LPR) and 
      radiation-induced mucositis has not been fully explored. In the present study, we 
      report 2 cases of laryngeal cancer in which radiation-induced mucositis 
      ameliorated after proton pump inhibitor (PPI) administration. Case 1 was 
      diagnosed with T1aN0M0 right glottis carcinoma and was treated with radiation 
      therapy. Grade 3 mucositis occurred after administration of 46Gy irradiation. PPI 
      was administered and mucositis ameliorated quickly without cessation of radiation 
      therapy. Case 2 was diagnosed with T2N0M0 supraglottic cancer and was treated 
      with concurrent chemoradiation therapy. Grade 3 mucositis occurred after 
      administration of 44Gy irradiation. PPI was administered and mucositis 
      ameliorated quickly without cessation of chemoradiation therapy. In both cases, a 
      remarkable therapeutic effect of PPI was observed in the perilaryngeal areas 
      including the epiglottic vallecula, arytenoid, and postcricoid area. In both 
      cases, LPR involvement was suspected before the onset of radiation therapy. The 
      two cases presented here, indicated a causal relationship between LPR and 
      radiation-induced mucositis. In cases of severe mucositis in the perilaryngeal 
      area in patients with LPR prior to radiation therapy, PPI administration may be 
      an effective therapeutic option.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Eguchi, Kohtaro
AU  - Eguchi K
AD  - Division of Head and Neck Surgery, Gunma Prefectural Cancer Center, Ota, Gunma, 
      Japan; Department of Clinical Anatomy, Tokyo Medical and Dental University 
      Graduate School, Bunkyo-ku, Tokyo, Japan. Electronic address: 
      kohtaro.eguchi@gmail.com.
FAU - Suzuki, Masami
AU  - Suzuki M
AD  - Division of Head and Neck Surgery, Gunma Prefectural Cancer Center, Ota, Gunma, 
      Japan.
FAU - Ida, Shota
AU  - Ida S
AD  - Division of Head and Neck Surgery, Gunma Prefectural Cancer Center, Ota, Gunma, 
      Japan.
FAU - Kudo, Shigehiro
AU  - Kudo S
AD  - Division of Radiation Oncology, Gunma Prefectural Cancer Center, Ota, Gunma, 
      Japan.
FAU - Ando, Ken
AU  - Ando K
AD  - Division of Radiation Oncology, Gunma Prefectural Cancer Center, Ota, Gunma, 
      Japan.
FAU - Ebara, Takeshi
AU  - Ebara T
AD  - Division of Radiation Oncology, Gunma Prefectural Cancer Center, Ota, Gunma, 
      Japan.
FAU - Higuchi, Keiko
AU  - Higuchi K
AD  - Division of Radiation Oncology, Isesaki Municipal Hospital, Isesaki, Gunma, 
      Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160602
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Carcinoma/*radiotherapy
MH  - Glottis
MH  - Humans
MH  - Laryngeal Neoplasms/*radiotherapy
MH  - Laryngitis/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Mucositis/*drug therapy
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Radiation Injuries/*drug therapy
OTO - NOTNLM
OT  - Head and neck cancer
OT  - Laryngopharyngeal reflux
OT  - Mucositis
OT  - Proton pump inhibitor
OT  - Radiation
EDAT- 2016/06/07 06:00
MHDA- 2017/03/07 06:00
CRDT- 2016/06/07 06:00
PHST- 2016/02/23 00:00 [received]
PHST- 2016/04/21 00:00 [revised]
PHST- 2016/05/13 00:00 [accepted]
PHST- 2016/06/07 06:00 [pubmed]
PHST- 2017/03/07 06:00 [medline]
PHST- 2016/06/07 06:00 [entrez]
AID - S0385-8146(16)30155-9 [pii]
AID - 10.1016/j.anl.2016.05.006 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2017 Feb;44(1):122-125. doi: 10.1016/j.anl.2016.05.006. Epub 
      2016 Jun 2.