PMID- 27265628
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160829
LR  - 20160606
IS  - 1300-7777 (Print)
IS  - 1300-7777 (Linking)
VI  - 26
IP  - 4
DP  - 2009 Dec 5
TI  - Incidence of anti-heparin/platelet factor 4 antibodies and heparin-induced 
      thrombocytopenia in medical patients.
PG  - 171-5
AB  - OBJECTIVE: Heparin-induced thrombocytopenia (HIT) is a life threatening 
      complication of heparin therapy, causing thrombosis. The aim of our study was to 
      find out the frequencies of HIT antibody seroconversion and clinical HIT in 
      Turkish medical patients on different forms of heparins. METHODS: Our study 
      included 61 patients who were on unfractionated heparin (UFH) (n: 37) and low 
      molecular weight heparin (LMWH) (n: 24) therapies. The frequency of HIT antibody 
      formation was determined by means of antigenic (ELISA), and functional assays 
      (serotonin release assay-SRA). RESULTS: The seroconversion rates in UFH and LMWH 
      groups were found to be 18.9% and 4.1% (ELISA), and 8.1% and 4.1% (SRA), 
      respectively. One patient (2.1%) on UFH therapy developed deep vein thrombosis. 
      No thromboembolic event was observed in patients taking LMWH. CONCLUSION: 
      Seroconversion rates by means of antigenic and functional assays and clinical HIT 
      were more common in patients on UFH than patients on LMWH therapy.
FAU - Demir, Muzaffer
AU  - Demir M
AD  - Trakya University, School of Medicine, Division of Hematology, 22030 Edirne, 
      Turkey, Phone: +90 284 235 76 42 - +90 284 235 10 41 E-mail: muzaffer@tnn.net.
FAU - Tekgunduz, Emre
AU  - Tekgunduz E
FAU - Edis, Mustafa
AU  - Edis M
FAU - Duran, Enver
AU  - Duran E
FAU - Kurum, Turan
AU  - Kurum T
FAU - Yigitbasi, Omer
AU  - Yigitbasi O
FAU - Yuksel, Mahmut
AU  - Yuksel M
LA  - eng
PT  - Journal Article
TT  - Medikal hastalarda anti-heparin trombosit faktor 4 antikor ve heparine bagli 
      trombositopeni sikligi.
PL  - Turkey
TA  - Turk J Haematol
JT  - Turkish journal of haematology : official journal of Turkish Society of 
      Haematology
JID - 9606065
EDAT- 2009/12/05 00:00
MHDA- 2009/12/05 00:01
CRDT- 2016/06/07 06:00
PHST- 2016/06/07 06:00 [entrez]
PHST- 2009/12/05 00:00 [pubmed]
PHST- 2009/12/05 00:01 [medline]
PST - ppublish
SO  - Turk J Haematol. 2009 Dec 5;26(4):171-5.