PMID- 27265791
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160829
LR  - 20160606
IS  - 1300-7777 (Print)
IS  - 1300-7777 (Linking)
VI  - 27
IP  - 1
DP  - 2010 Mar 5
TI  - Mixed chimerism following hematopoietic stem cell transplantation in pediatric 
      thalassemia major patients: a single center experience.
PG  - 8-14
AB  - OBJECTIVE: Stable mixed chimerism (MC) may result in cure for thalassemia major 
      patients following hematopoietic stem cell transplantation (HSCT), but rejection 
      can occur. Twenty-eight HSCTs for thalassemia major were reviewed retrospectively 
      to evaluate the clinical course of MC with possible risk factors and predictors 
      of outcome, with a median follow-up of 1669 days (811-3576 days). METHODS: 
      Chimerism was detected by fluorescence in situ hybridization (FISH) or multiplex 
      polymerase chain reaction depending on the sex match between the donor and the 
      recipient. RESULTS: Primary rejection, stable MC and full donor chimerism was 
      detected in 3.6%, 17.8% and 78.6% of patients, respectively. Clinically, 4/5 
      patients with stable MC had thalassemia trait with donor chimerism as low as 14%. 
      One patient was started on pRBC transfusions at 2.5 years postHSCT. CONCLUSION: 
      Stable MC can result in cure for thalassemia major patients. The clinical picture 
      remains as the best guide for intervention until a more reliable predictor is 
      available.
FAU - Unal Ince, Elif
AU  - Unal Ince E
AD  - Department of Pediatric Hematology, Ankara University Faculty of Medicine, 
      Dikimevi 06100, Ankara, Turkey Phone: +90 0312 595 69 06 E-mail: 
      elifunal@msn.com.
FAU - Ertem, Mehmet
AU  - Ertem M
FAU - Ileri, Talia
AU  - Ileri T
FAU - Dalva, Klara
AU  - Dalva K
FAU - Topcuoglu, Pervin
AU  - Topcuoglu P
FAU - Uysal, Zumrut
AU  - Uysal Z
LA  - eng
PT  - Journal Article
TT  - Pediatrik talasemi major hastalarinda hematopoetik kok hucre nakli sonrasi 
      karisik tip kimerizm-tek merkez sonuclari.
PL  - Turkey
TA  - Turk J Haematol
JT  - Turkish journal of haematology : official journal of Turkish Society of 
      Haematology
JID - 9606065
EDAT- 2010/03/05 00:00
MHDA- 2010/03/05 00:01
CRDT- 2016/06/07 06:00
PHST- 2016/06/07 06:00 [entrez]
PHST- 2010/03/05 00:00 [pubmed]
PHST- 2010/03/05 00:01 [medline]
PST - ppublish
SO  - Turk J Haematol. 2010 Mar 5;27(1):8-14.