PMID- 27267362
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20220331
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 16
DP  - 2016 Jun 7
TI  - Diagnostic accuracy of cardiovascular magnetic resonance for patients with 
      suspected cardiac amyloidosis: a systematic review and meta-analysis.
PG  - 129
LID - 10.1186/s12872-016-0311-6 [doi]
LID - 129
AB  - BACKGROUND: This study is a systematic review and meta-analysis of the diagnostic 
      value of cardiovascular magnetic resonance (CMR) in cardiac amyloidosis (CA). 
      METHODS: A wide variety of electronic databases were searched for studies of CMR 
      that reported the diagnostic accuracy in patients with suspected CA. Research 
      manuscripts were subjected to further systematic review and meta-analysis. 
      Methodological evaluation was performed under the guidance of the Quality 
      Assessment of Diagnostic Accuracy Studies -2 (QUADAS-2). Heterogeneity was 
      assessed, and a random-effects model was used to assess the diagnostic effects of 
      CMR on pooled sensitivity, pooled specificity, and summary receiver operating 
      characteristics (SROC). RESULTS: Seven studies that reported the performance of 
      CMR for CA were included in the present systematic review, among which five 
      studies (257 patients) that evaluated the diagnostic accuracy of late gadolinium 
      enhancement (LGE) CMR were analyzed in the present meta-analysis. Heterogeneity 
      was observed only in specificity. A summary sensitivity and specificity of 85 % 
      (95 % CI: 77-91 %) and 92 % (95 % CI: 83-97 %) indicated a high diagnostic 
      accuracy of LGE for CA. The AUC of SROC curve was 0.9530, suggesting that LGE is 
      an effective way of diagnosing patients with possible cardiac involvement in 
      amyloidosis. CONCLUSIONS: LGE-CMR seems to have a relatively high diagnostic 
      accuracy for amyloidosis patients with possible cardiac involvement. Combined CMR 
      techniques may provide important information for the selection of suitable 
      therapy.
FAU - Zhao, Lei
AU  - Zhao L
AD  - Department of Cardiology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan, 
      Wangfujing, Dongcheng District, Beijing, 100730, China.
FAU - Tian, Zhuang
AU  - Tian Z
AD  - Department of Cardiology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan, 
      Wangfujing, Dongcheng District, Beijing, 100730, China.
FAU - Fang, Quan
AU  - Fang Q
AD  - Department of Cardiology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, No.1 Shuaifuyuan, 
      Wangfujing, Dongcheng District, Beijing, 100730, China. quanfangxjn2013@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20160607
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - Amyloidosis/*diagnostic imaging/pathology
MH  - Area Under Curve
MH  - Cardiomyopathies/*diagnostic imaging/pathology
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - ROC Curve
MH  - Reproducibility of Results
PMC - PMC4897958
OTO - NOTNLM
OT  - Cardiac amyloidosis
OT  - Cardiac magnetic resonance
OT  - LGE
OT  - Meta-analysis
EDAT- 2016/06/09 06:00
MHDA- 2017/10/17 06:00
PMCR- 2016/06/07
CRDT- 2016/06/09 06:00
PHST- 2015/07/11 00:00 [received]
PHST- 2016/05/31 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
PHST- 2016/06/07 00:00 [pmc-release]
AID - 10.1186/s12872-016-0311-6 [pii]
AID - 311 [pii]
AID - 10.1186/s12872-016-0311-6 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2016 Jun 7;16:129. doi: 10.1186/s12872-016-0311-6.