PMID- 27267870
OWN - NLM
STAT- MEDLINE
DCOM- 20170407
LR  - 20170407
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 203
DP  - 2016 Aug
TI  - Cross sectional, comparative study of serum erythropoietin, transferrin receptor, 
      ferritin levels and other hematological indices in normal pregnancies and iron 
      deficiency anemia during pregnancy.
PG  - 99-103
LID - S0301-2115(16)30236-6 [pii]
LID - 10.1016/j.ejogrb.2016.05.022 [doi]
AB  - OBJECTIVE: To test the correlation of the serum erythropoietin levels, serum 
      transferrrin receptor levels and serum ferritin levels along with other 
      hematological parameters in normal pregnant and anemic pregnant patients. STUDY 
      DESIGN: In a prospective study, 120 pregnant women were recruited between 18 and 
      36 weeks of gestation; 53 normal pregnant patients, 67 anemic pregnant patients, 
      in which, 17 had mild, 30 had moderate anemia, 20 had severe anemia. A blood 
      sample was taken. The various hematological parameters, hemoglobin (Hb), mean 
      corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), total 
      iron binding capacity (TIBC), serum ferritin, percentage saturation of iron, 
      serum erythropoietin (SEPO) levels, serum transferrin receptors (STfRS) were 
      performed. For statistics, Student's 't' test, Pearson's Chi test, Mann Whitney 
      test and Bartlett test were used as per data. RESULTS AND CONCLUSION: MCV was 
      significantly reduced in anemic pregnancies as compared to non-anemic pregnancies 
      (80.2+/-9.6 vs 94.12+/-9.8fl, p=0.001), MCHC was also reduced in them (30.2+/-3.38% vs 
      34.2+/-2.33%, p=0.176), TIBC was significantly increased in anemic pregnancies 
      (343.31+/-28.54% vs 322.88+/-23.84%, p=0.001), serum ferritin was significantly 
      reduced (24.9+/-10.48mug/L vs 31.03+/-9.98mug/L, p=0.001), percentage saturation of 
      iron was also reduced (53.85+/-13.21% vs 62.04+/-15.79%, p=0.0024), serum 
      erythropoietin levels were significantly higher in anemic women (26.24+/-26.61mU/ml 
      vs 18.12+/-19.08mU/ml, p=0.064). The levels were significantly higher in severe 
      anemia (46.5+/-46.8mU/ml than in moderate anemia 27.4+/-28.1mU/ml and mild anemia 
      22.8+/-22.8mU/ml. Serum transferrin receptors were significantly higher in anemic 
      pregnancies than in non-anemic pregnancies (1.40+/-0.0802mug/ml vs 1.08+/-0.641mug/ml, 
      p=0.019) with rise being higher in severe anemia (2.28+/-0.986mug/ml) than in 
      moderate (1.4+/-0.816mug/ml) and mild anemia (1.16+/-0.702mug/ml). CONCLUSION: Various 
      hematological parameters especially sTfR, serum erythropoietin, serum ferritin 
      and sTfR/log ferritin levels correlate with the severity of anemia.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Sharma, Jai B
AU  - Sharma JB
AD  - Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, 
      New Delhi, India. Electronic address: jbsharma2000@gmail.com.
FAU - Bumma, Sirisha D
AU  - Bumma SD
AD  - Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, 
      New Delhi, India.
FAU - Saxena, Renu
AU  - Saxena R
AD  - Department of Hematology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Kumar, Sunesh
AU  - Kumar S
AD  - Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, 
      New Delhi, India.
FAU - Roy, Kallol K
AU  - Roy KK
AD  - Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, 
      New Delhi, India.
FAU - Singh, Neeta
AU  - Singh N
AD  - Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, 
      New Delhi, India.
FAU - Vanamail, P
AU  - Vanamail P
AD  - Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 
      India.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160520
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
RN  - 0 (Receptors, Transferrin)
RN  - 11096-26-7 (Erythropoietin)
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Iron-Deficiency/*blood
MH  - Cross-Sectional Studies
MH  - Erythropoietin/*blood
MH  - Female
MH  - Ferritins/*blood
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/*blood
MH  - Prospective Studies
MH  - Receptors, Transferrin/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Blood indices
OT  - Iron deficiency anemia
OT  - Pregnancy
OT  - Serum erythropoietin levels
OT  - Serum transferrin receptor levels
EDAT- 2016/06/09 06:00
MHDA- 2017/04/08 06:00
CRDT- 2016/06/09 06:00
PHST- 2016/03/11 00:00 [received]
PHST- 2016/05/12 00:00 [revised]
PHST- 2016/05/13 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/04/08 06:00 [medline]
AID - S0301-2115(16)30236-6 [pii]
AID - 10.1016/j.ejogrb.2016.05.022 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2016 Aug;203:99-103. doi: 
      10.1016/j.ejogrb.2016.05.022. Epub 2016 May 20.