PMID- 27268619
OWN - NLM
STAT- MEDLINE
DCOM- 20170131
LR  - 20170308
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 17
IP  - 5
DP  - 2016
TI  - Susceptible and Protective Associations of HLA Alleles and Haplotypes with 
      Cervical Cancer in South India.
PG  - 2491-7
AB  - BACKGROUND: Human leukocyte antigen (HLA) genes have been implicated in cervical 
      cancer in several populations. OBJECTIVES: To study the predispositions of HLA 
      alleles/haplotypes with cervical cancer. MATERIALS AND METHODS: Clinically 
      diagnosed and PAP smear confirmed cervical cancer patients (n 48) and age matched 
      controls (n 47) were genotyped for HLA-A,-B,-DRB1* and DQB1* alleles by PCR-SSP 
      methods. RESULTS: The frequencies of alleles DRB1*04 (OR=2.57), DRB1*15 
      (OR=2.04), DQB1*0301 (OR=4.91), DQB1*0601 (OR=2.21), B*15 (OR=13.03) and B*07 
      (OR=6.23) were higher in cervical cancer patients than in the controls. The 
      frequencies of alleles DRB1*10 (OR=0.22) and B*35 (OR=0.19) were decreased. 
      Strong disease associations were observed for haplotypes DRB1*15-DQB1*0601 
      (OR=6.56; < 3.5.10-4), DRB1*14-DQB1*0501 (OR=6.51; <0.039) and A*11-B*07 
      (OR=3.95; <0.005). The reduced frequencies of haplotypes DRB1*10-DQB1*0501 
      (OR=0.45), A*03-B*35 (OR=0.25) and A*11-B*35 (OR= 0.06) among patients suggested 
      a protective association. HLA-C* typing of 8 patients who possessed a unique 
      three locus haplotype 'A*11-B*07-DRB1*04' (8/48; 16.66%; OR=6.51; <0.039) 
      revealed the presence of a four locus haplotype 'A*11-B*07-C*01-DRB1*04' in 
      patients (4/8; 50%). Amino acid variation analysis of susceptible allele 
      DQB1*0601 suggested 'tyrosine' at positions beta9 and beta37 and tyrosine-non-tyrosine 
      genotype combination increased the risk of cervical cancer. CONCLUSIONS: Strong 
      susceptible associations were documented for HLA alleles B*15, B*07, DRB1*04, 
      DRB1*15, DQB1*0301, DQB1*0601 and haplotypes DRB1*15-DQB1*0601 and 
      DRB1*14-DQB1*0501. Further, protective associations were evidenced for alleles 
      B*35 and DRB1*10 and haplotypes A*11-B*35 and DRB1*10-DQB1*0501 with cervical 
      cancer in South India.
FAU - Rathika, Chinniah
AU  - Rathika C
AD  - Department of Immunology, School of Biological Sciences, Madurai Kamaraj 
      University, Madurai, India E-mail : immunobala@ mkuniversity.org.
FAU - Murali, Vijayan
AU  - Murali V
FAU - Dhivakar, Mani
AU  - Dhivakar M
FAU - Kamaraj, Raju
AU  - Kamaraj R
FAU - Malini, Ravi Padma
AU  - Malini RP
FAU - Ramgopal, Sivanadham
AU  - Ramgopal S
FAU - Balakrishnan, Karuppiah
AU  - Balakrishnan K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-C Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - India/epidemiology
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single-Stranded Conformational
MH  - Prevalence
MH  - Prognosis
MH  - Uterine Cervical Neoplasms/epidemiology/*genetics/prevention & control
EDAT- 2016/06/09 06:00
MHDA- 2017/02/01 06:00
CRDT- 2016/06/09 06:00
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/02/01 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2016;17(5):2491-7.