PMID- 27268965
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180711
LR  - 20180711
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 8
IP  - 26
DP  - 2016 Jul 6
TI  - Predictive Model for the Design of Zwitterionic Polymer Brushes: A Statistical 
      Design of Experiments Approach.
PG  - 16595-603
LID - 10.1021/acsami.6b04370 [doi]
AB  - The performance of polymer interfaces in biology is governed by a wide spectrum 
      of interfacial properties. With the ultimate goal of identifying design 
      parameters for stem cell culture coatings, we developed a statistical model that 
      describes the dependence of brush properties on surface-initiated polymerization 
      (SIP) parameters. Employing a design of experiments (DOE) approach, we identified 
      operating boundaries within which four gel architecture regimes can be realized, 
      including a new regime of associated brushes in thin films. Our statistical model 
      can accurately predict the brush thickness and the degree of intermolecular 
      association of poly[2-(methacryloyloxy) ethyl dimethyl-(3-sulfopropyl) ammonium 
      hydroxide] (PMEDSAH), a previously reported synthetic substrate for feeder-free 
      and xeno-free culture of human embryonic stem cells. DOE-based multifunctional 
      predictions offer a powerful quantitative framework for designing polymer 
      interfaces. For example, model predictions can be used to decrease the critical 
      thickness at which the wettability transition occurs by simply increasing the 
      catalyst quantity from 1 to 3 mol %.
FAU - Kumar, Ramya
AU  - Kumar R
AD  - Department of Chemical Engineering, double daggerDepartment of Macromolecular Science & 
      Engineering,  section signDepartment of Material Science & Engineering,  perpendicularDepartment of 
      Biomedical Engineering, and  parallelBiointerfaces Institute, University of Michigan , 
      Ann Arbor, Michigan 48109, United States.
FAU - Lahann, Joerg
AU  - Lahann J
AD  - Department of Chemical Engineering, double daggerDepartment of Macromolecular Science & 
      Engineering,  section signDepartment of Material Science & Engineering,  perpendicularDepartment of 
      Biomedical Engineering, and  parallelBiointerfaces Institute, University of Michigan , 
      Ann Arbor, Michigan 48109, United States.
LA  - eng
PT  - Journal Article
DEP - 20160621
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
OTO - NOTNLM
OT  - PMEDSAH
OT  - response surface methodology
OT  - stem cell culture
OT  - surface-initiated atom transfer radical polymerization
OT  - zwitterionic self-association
EDAT- 2016/06/09 06:00
MHDA- 2016/06/09 06:01
CRDT- 2016/06/09 06:00
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2016/06/09 06:01 [medline]
AID - 10.1021/acsami.6b04370 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2016 Jul 6;8(26):16595-603. doi: 
      10.1021/acsami.6b04370. Epub 2016 Jun 21.