PMID- 27269659
OWN - NLM
STAT- MEDLINE
DCOM- 20170504
LR  - 20171219
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 496
DP  - 2016 Sep
TI  - Newcastle disease virus infection induces activation of the NLRP3 inflammasome.
PG  - 90-96
LID - S0042-6822(16)30132-5 [pii]
LID - 10.1016/j.virol.2016.05.023 [doi]
AB  - Inflammatory responses are important aspects of the innate immune system during 
      virus infection. We found that Newcastle disease virus can induce inflammasome 
      activation in the human macrophage-like cell line THP-1. Viral replication was 
      required for inflammasome activation, and small hairpin RNA knockdown experiments 
      indicated that IL-1beta secretion was mediated by the NLRP3 inflammasome. We also 
      verified the results in LPS-primed bone marrow-derived macrophages (BMDMs) from 
      NLRP3-deficient and wild type mice. NDV is considered to be a promising oncolytic 
      virus. Stimulating the immune system has been proposed as a key mechanism of 
      oncolytic specificity, and the inflammasome appears to be an important mechanism 
      by which NDV is controlled. Knockdown of inflammasome components or chemical 
      inhibition of caspase-1 activity shows that cell survival was augmented and 
      benefited NDV replication. This study shows that NLRP3 inflammasome activation is 
      an innate cellular response to NDV infection and offers insights into the 
      oncolytic specificity of NDV.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Wang, Binbin
AU  - Wang B
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Zhu, Jie
AU  - Zhu J
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Li, Dandan
AU  - Li D
AD  - College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 
      712100, China.
FAU - Wang, Yang
AU  - Wang Y
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Zhan, Yuan
AU  - Zhan Y
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Tan, Lei
AU  - Tan L
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Qiu, Xusheng
AU  - Qiu X
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Sun, Yingjie
AU  - Sun Y
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Song, Cuiping
AU  - Song C
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Meng, Chunchun
AU  - Meng C
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Ying, Liao
AU  - Ying L
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Xiang, Mao
AU  - Xiang M
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
FAU - Meng, Guangxun
AU  - Meng G
AD  - Unit of Innate Immunity, Key Laboratory of Molecular Virology & Immunology, 
      Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, 
      Chinese Academy of Sciences, Shanghai 200031, China.
FAU - Ding, Chan
AU  - Ding C
AD  - Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China. Electronic 
      address: shoveldeen@shvri.ac.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160603
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Caspase Inhibitors)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - EC 3.4.22.36 (Caspase 1)
SB  - IM
MH  - Animals
MH  - Caspase 1/metabolism
MH  - Caspase Inhibitors/pharmacology
MH  - Cell Line
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Inflammasomes/*metabolism
MH  - Interleukin-1beta/biosynthesis
MH  - Macrophage Activation/immunology
MH  - Macrophages/immunology/metabolism/virology
MH  - Mice
MH  - Mice, Knockout
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/genetics/*metabolism
MH  - Newcastle Disease/genetics/*metabolism/*virology
MH  - Newcastle disease virus/*physiology
MH  - Virus Replication
OTO - NOTNLM
OT  - Caspase-1
OT  - Inflammasome
OT  - NDV
OT  - NLRP3
OT  - THP-1 cells
EDAT- 2016/06/09 06:00
MHDA- 2017/05/05 06:00
CRDT- 2016/06/09 06:00
PHST- 2016/02/08 00:00 [received]
PHST- 2016/04/24 00:00 [revised]
PHST- 2016/05/26 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/05/05 06:00 [medline]
AID - S0042-6822(16)30132-5 [pii]
AID - 10.1016/j.virol.2016.05.023 [doi]
PST - ppublish
SO  - Virology. 2016 Sep;496:90-96. doi: 10.1016/j.virol.2016.05.023. Epub 2016 Jun 3.