PMID- 27269955
OWN - NLM
STAT- MEDLINE
DCOM- 20170316
LR  - 20170817
IS  - 1532-8171 (Electronic)
IS  - 0735-6757 (Linking)
VI  - 34
IP  - 8
DP  - 2016 Aug
TI  - High immunoglobulin E values at admission predict mortality in ED patients with 
      sepsis.
PG  - 1589-94
LID - S0735-6757(16)30195-4 [pii]
LID - 10.1016/j.ajem.2016.05.062 [doi]
AB  - OBJECTIVES: Gamma immunoglobulin E (IgE) is associated with allergic reactions 
      but has not been described as being activated after sepsis. This study aimed at 
      detecting the prognostic value of plasma IgE level in sepsis progression in the 
      emergency department (ED). METHODS: Plasma IgE and related cytokines levels were 
      measured on enrollment, and the Acute Physiology and Chronic Health Evaluation II 
      score, Sequential Organ Failure Assessment score, and Mortality in Emergency 
      Department Sepsis score were calculated on ED admission. A 28-day follow-up was 
      performed for all patients. RESULTS: A total of 480 patients were consecutively 
      enrolled in this study. The results revealed that nonsurvivors were in a more 
      severe critical state, with reflected by higher IgE level and higher scoring 
      systems (P<.001). Multivariate logistic regression analysis showed that IgE level 
      was independent predictor of severe sepsis (odds ratio, 1.034; 95% confidence 
      interval, 1.023-1.044; P<.001) and 28-day mortality (odds ratio, 1.038; 95% 
      confidence interval, 1.027-1.053; P<.001). The areas under the receiver operating 
      characteristic curve (AUC) analysis showed that IgE was a useful parameter in 
      prognosis of severe sepsis (AUC was 0.830; cutoff value was 303.08mug/L) and 
      28-day mortality (AUC was 0.700; cutoff value was 299.96mug/L), Importantly, the 
      AUC of combination of IgE and Mortality in Emergency Department Sepsis score 
      performed for the most significant prognostic ability than each parameter, 
      respectively, in this cohort (P<.001). CONCLUSIONS: The results of this study 
      indicate that septic patients with higher IgE level present with higher risk of 
      mortality, and a combination of IgE level with scoring systems significantly 
      increased the predictive accuracy for severe sepsis and 28-day mortality.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Dong, Guijuan
AU  - Dong G
AD  - Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhao, Xin
AU  - Zhao X
AD  - Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, China.
FAU - Li, Chun-Sheng
AU  - Li CS
AD  - Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, China. Electronic address: lcscyyy@163.com.
LA  - eng
PT  - Journal Article
DEP - 20160526
PL  - United States
TA  - Am J Emerg Med
JT  - The American journal of emergency medicine
JID - 8309942
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Am J Emerg Med. 2016 Aug;34(8):1714. PMID: 27324850
MH  - Aged
MH  - Biomarkers/blood
MH  - China/epidemiology
MH  - *Emergency Service, Hospital
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - *Patient Admission
MH  - Prognosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Sepsis/blood/*mortality
MH  - Survival Rate/trends
EDAT- 2016/06/09 06:00
MHDA- 2017/03/17 06:00
CRDT- 2016/06/09 06:00
PHST- 2016/03/08 00:00 [received]
PHST- 2016/05/18 00:00 [revised]
PHST- 2016/05/24 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/03/17 06:00 [medline]
AID - S0735-6757(16)30195-4 [pii]
AID - 10.1016/j.ajem.2016.05.062 [doi]
PST - ppublish
SO  - Am J Emerg Med. 2016 Aug;34(8):1589-94. doi: 10.1016/j.ajem.2016.05.062. Epub 
      2016 May 26.