PMID- 27270865
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180119
LR  - 20180119
IS  - 1096-9888 (Electronic)
IS  - 1076-5174 (Linking)
VI  - 51
IP  - 6
DP  - 2016 Jun
TI  - Surface acoustic wave nebulization device with dual interdigitated transducers
      improves SAWN-MS performance.
PG  - 424-9
LID - 10.1002/jms.3766 [doi]
AB  - We compared mass spectrometric (MS) performance of surface acoustic wave
      nebulization (SAWN) generated by a single interdigitated transducer (IDT)
      designed to produce a progressive wave (PW) to one with a dual IDT that can in
      theory generate standing waves (SW). Given that devices using dual IDTs had been 
      shown to produce fewer large size droplets on average, we hypothesized they would
      improve MS performance by improving the efficiency of desolvation. Indeed, the
      SW-SAWN chip provided an improved limit of detection of 1 femtomole of peptide
      placed on chip making it 100x more sensitive than the PW design. However, as
      measured by high-speed image recording and phase Doppler particle analyzer
      measurements, there was only a 26% increase in the small diameter (1-10 microm)
      droplets produced from the new device, precluding a conclusion that the decrease 
      in droplet size was solely responsible for the improvement in MS signal/noise.
      Given that the dual IDT design produced a more instantaneous plume than the PW
      design, the more likely contributor to improved MS signal/noise was concluded to 
      be a higher ion flux entering the mass spectrometer for the dual IDT designs.
      Notably, the dual IDT device allowed production of much higher quality protein
      mass spectra up to about 20 kDa, compared with the single IDT device. Copyright
      (c) 2016 John Wiley & Sons, Ltd.
CI  - Copyright (c) 2016 John Wiley & Sons, Ltd.
FAU - Huang, Yue
AU  - Huang Y
AD  - Deurion, LLC, Seattle, WA, USA.
FAU - Heron, Scott R
AU  - Heron SR
AD  - Deurion, LLC, Seattle, WA, USA.
FAU - Clark, Alicia M
AU  - Clark AM
AD  - Department of Mechanical Engineering, University of Washington, Seattle, WA, USA.
FAU - Edgar, J Scott
AU  - Edgar JS
AD  - Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
FAU - Yoon, Sung Hwan
AU  - Yoon SH
AD  - Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD,
      USA.
FAU - Kilgour, David P A
AU  - Kilgour DP
AD  - School of Science & Technology, Nottingham Trent University, Nottingham, UK.
FAU - Turecek, Frantisek
AU  - Turecek F
AD  - Department of Chemistry, University of Washington, Seattle, WA, USA.
FAU - Aliseda, Alberto
AU  - Aliseda A
AD  - Department of Mechanical Engineering, University of Washington, Seattle, WA, USA.
FAU - Goodlett, David R
AU  - Goodlett DR
AD  - Deurion, LLC, Seattle, WA, USA.
AD  - Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD,
      USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Mass Spectrom
JT  - Journal of mass spectrometry : JMS
JID - 9504818
OTO - NOTNLM
OT  - SAWN
OT  - SAWN-MS
OT  - mass spectrometry
OT  - standing wave
OT  - surface acoustic wave nebulization
EDAT- 2016/06/09 06:00
MHDA- 2016/06/09 06:01
CRDT- 2016/06/09 06:00
PHST- 2015/12/25 00:00 [received]
PHST- 2016/03/13 00:00 [revised]
PHST- 2016/03/21 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2016/06/09 06:01 [medline]
AID - 10.1002/jms.3766 [doi]
PST - ppublish
SO  - J Mass Spectrom. 2016 Jun;51(6):424-9. doi: 10.1002/jms.3766.