PMID- 27271257
OWN - NLM
STAT- MEDLINE
DCOM- 20170817
LR  - 20181113
IS  - 1432-1963 (Electronic)
IS  - 0172-8113 (Linking)
VI  - 37
IP  - 4
DP  - 2016 Jul
TI  - [Sarcoma of the spleen with MDM2 expression].
PG  - 367-70
LID - 10.1007/s00292-016-0168-6 [doi]
AB  - Primary sarcomas and sarcoma metastases are a rarity in the spleen. We report on 
      the case of a 69-year-old male patient presenting with unclear abdominal symptoms 
      and computed tomography (CT) revealed a tumor mass in the spleen. Histologically 
      the tumor mass predominantly showed features of a spindle cell sarcoma with 
      lymphoid infiltrates. The expression and amplification of MDM2 could be 
      demonstrated by means of immunohistochemistry and fluorescence in situ 
      hybridization (FISH). Furthermore, staging examinations did not reveal 
      indications of any other primary tumors. These preliminary findings were 
      suggestive of a dedifferentiated liposarcoma; however, in the further diagnostic 
      work-up the tumor showed strong expression of CD21 and CD23 and was ultimately 
      diagnosed as a follicular dendritic cell sarcoma (FDCS). The case emphasizes that 
      MDM2 expression represents a possible pitfall in the diagnosis of spindle cell 
      tumors. The differential diagnostic distinction between FDCS and a 
      dedifferentiated liposarcoma is discussed.
FAU - Hansen, T
AU  - Hansen T
AD  - Institut fur Pathologie, Klinikum Lippe GmbH, Detmold und Lemgo, 
      Rontgenstrasse 18, 32756, Detmold, Deutschland. Torsten.Hansen@klinikum-lippe.de.
FAU - Titze, U
AU  - Titze U
AD  - Institut fur Pathologie, Klinikum Lippe GmbH, Detmold und Lemgo, 
      Rontgenstrasse 18, 32756, Detmold, Deutschland.
FAU - Deeb, A
AU  - Deeb A
AD  - Klinik fur Urologie, Klinikum Lippe GmbH, Detmold und Lemgo, Detmold, 
      Deutschland.
FAU - Eikotter, B
AU  - Eikotter B
AD  - Klinik fur Allgemein-, Viszeral - und Thoraxchirurgie, Klinikum Lippe GmbH, 
      Detmold und Lemgo, Detmold, Deutschland.
FAU - Schutz, M
AU  - Schutz M
AD  - Institut fur Diagnostische und Interventionelle Radiologie, Klinikum Lippe GmbH, 
      Detmold und Lemgo, Detmold, Deutschland.
FAU - Schildhaus, H U
AU  - Schildhaus HU
AD  - Institut fur Pathologie, Universitatsmedizin Gottingen, Gottingen, Deutschland.
LA  - ger
PT  - Case Reports
PT  - Journal Article
TT  - Sarkom der Milz mit MDM2-Expression.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
RN  - EC 2.3.2.27 (MDM2 protein, human)
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
SB  - IM
MH  - Aged
MH  - Diagnosis, Differential
MH  - Humans
MH  - Liposarcoma/*genetics/*pathology/surgery
MH  - Male
MH  - Proto-Oncogene Proteins c-mdm2/*genetics
MH  - Sarcoma/*genetics/*pathology/surgery
MH  - Spleen/pathology
MH  - Splenectomy
MH  - Splenic Neoplasms/*genetics/*pathology/surgery
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - CD23
OT  - Dedifferentiated liposarcoma
OT  - Fluorescence in situ hybridization
OT  - Follicular dendritic cell sarcoma
OT  - Immunohistochemistry
EDAT- 2016/06/09 06:00
MHDA- 2017/08/18 06:00
CRDT- 2016/06/09 06:00
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
AID - 10.1007/s00292-016-0168-6 [pii]
AID - 10.1007/s00292-016-0168-6 [doi]
PST - ppublish
SO  - Pathologe. 2016 Jul;37(4):367-70. doi: 10.1007/s00292-016-0168-6.