PMID- 27271351
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20221207
IS  - 2005-6648 (Electronic)
IS  - 1226-3303 (Print)
IS  - 1226-3303 (Linking)
VI  - 31
IP  - 4
DP  - 2016 Jul
TI  - Poor glycemic control is associated with the risk of subclinical hypothyroidism 
      in patients with type 2 diabetes mellitus.
PG  - 703-11
LID - 10.3904/kjim.2015.198 [doi]
AB  - BACKGROUND/AIMS: Overt hypothyroidism is frequently found in patients with type 2 
      diabetes mellitus (T2DM), but it remains unknown the relationship between 
      subclinical hypothyroidism (SCH) and T2DM. We attempt to evaluate the difference 
      in prevalence of SCH between patients with T2DM and general population, and the 
      association between SCH and glycemic control status ofdiabetic patients. METHODS: 
      This was cross-sectional study. Total 8,528 subjects who visited for health 
      check-up were recruited. SCH was defined as an elevated level of serum thyroid 
      stimulating hormone (> 4.0 mIU/L) with a normal level of free thyroxine. T2DM 
      group was categorized into three groups by glycosylated hemoglobin (HbA1c): < 7% 
      (reference), >/= 7% and < 9%, >/= 9%. RESULTS: Finally, 7,966 subjects were included. 
      The prevalence of SCH was not different between healthy controls and subjects 
      with T2DM (8.1% vs. 7.4%, p = 0.533; in men, 5.7% vs. 5.1%, p = 0.573; in women, 
      10.9% vs. 11.7%, p = 0.712), but it was increased with highest HbA1c group more 
      than well controlled group, especially in women. The risk of SCH was increased by 
      group with poorer glycemic control; the odds ratio for HbA1c >/= 9% compared to < 
      7% was 2.52 (95% confidence interval [CI], 1.09 to 5.86; p = 0.031), and 4.58 
      (95% CI, 1.41 to 14.87; p = 0.011) in women, but not significant in men. 
      CONCLUSIONS: The prevalence of SCH was similar between T2DM and healthy group. 
      Poor glycemic control in T2DM was obviously associated with the risk of SCH, 
      especially in elderly women. These results suggest SCH as comorbidity may be 
      considered in elderly women with poor glycemic control.
FAU - Cho, Jae Ho
AU  - Cho JH
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Kim, Ho Jin
AU  - Kim HJ
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Lee, Jun Ho
AU  - Lee JH
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Park, Il Rae
AU  - Park IR
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Moon, Jun Sung
AU  - Moon JS
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Yoon, Ji Sung
AU  - Yoon JS
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Lee, In-Kyu
AU  - Lee IK
AD  - Department of Internal Medicine, Kyungpook National University School of 
      Medicine, Daegu, Korea.
FAU - Won, Kyu Chang
AU  - Won KC
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Lee, Hyoung Woo
AU  - Lee HW
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20160608
PL  - Korea (South)
TA  - Korean J Intern Med
JT  - The Korean journal of internal medicine
JID - 8712418
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Asymptomatic Diseases
MH  - Biomarkers/blood
MH  - Blood Glucose/*drug effects/metabolism
MH  - Chi-Square Distribution
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/*drug therapy/epidemiology
MH  - Female
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Hypothyroidism/blood/diagnosis/*epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Prevalence
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Sex Distribution
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
PMC - PMC4939501
OTO - NOTNLM
OT  - Diabetes mellitus, type 2
OT  - Hemoglobin A, glycosylated
OT  - Subclinical hypothyroidism
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2016/06/09 06:00
MHDA- 2017/05/16 06:00
PMCR- 2016/07/01
CRDT- 2016/06/09 06:00
PHST- 2015/06/30 00:00 [received]
PHST- 2015/08/14 00:00 [revised]
PHST- 2015/09/07 00:00 [accepted]
PHST- 2016/06/09 06:00 [entrez]
PHST- 2016/06/09 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - kjim.2015.198 [pii]
AID - kjim-2015-198 [pii]
AID - 10.3904/kjim.2015.198 [doi]
PST - ppublish
SO  - Korean J Intern Med. 2016 Jul;31(4):703-11. doi: 10.3904/kjim.2015.198. Epub 2016 
      Jun 8.